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Dr. Apurva Chatrath

Biography

Dr. Apurva Chatrath is a researcher with a distinguished academic background and expertise in microbial proteomics and genetics. She earned her Bachelor’s degree in Botany (Hons.) from University of Delhi, graduating with the first class across all three years. She subsequently completed her Master’s degree in Life Sciences from Indira Gandhi National Open University, New Delhi (On-campus), and went on to pursue a Ph.D. in Biotechnology at the Indian Institute of Technology (IIT) Roorkee. Her doctoral thesis on antibiofilm activities and proteomic analysis of Candida tropicalis in response to various bioactive compounds, focused on elucidating proteome profiles and metabolic changes during antimicrobial incursions. She successfully identified and categorized the citral-induced proteins, providing key insights into tolerance of citral by C. tropicalis, protein misfolding and aggregation under oxidative stress. Her findings offered valuable contributions to the translational application of fungal-derived compounds in biofilm management. Following her Ph.D., Dr. Chatrath undertook Research Associateship in CSIR funded project at ICAR- Indian Agricultural Research Institute, where she deciphered the salinity induced proteome profiling of Azolla and its symbionts. Later she pursued the postdoctoral research at the University at Buffalo, State University of New York for three years, where she conducted advanced studies on Neurospora crassa cell wall glycoproteins, exploring the gene functions in glycoprotein synthesis, transport, and integration into the eukaryotic cell wall. Aa a prolific researcher, Dr. Chatrath has published 11 peer-reviewed research and review articles with leading international publishers including MDPI, Elsevier, and Springer. She has also qualified several national-level examinations, including CSIR-JRF, ICMR-JRF, and GATE.

Research Highlights

Dr. Apurva Chatrath’s research focuses in microbial proteomics, fungal biology, and stress physiology, with research spanning pathogenic fungi, cyanobacterial symbionts, and eukaryotic model systems. In her Postdoctoral research at the University at Buffalo, SUNY, she investigated cell wall biogenesis in Neurospora crassa. Her work focuses on elucidating the roles of glycoproteins in cell wall assembly, including their synthesis, trafficking, and integration. She has developed experimental pipelines for generating targeted mutants, purifying cell wall-associated proteins, and conducting enzymatic assays, contributing to a mechanistic understanding of fungal cell wall organization and its implications for antifungal strategies. Her doctoral research at IIT Roorkee cantered on the antibiofilm activity and proteomic responses of Candida tropicalis to terpenes. Through quantitative proteomic analyses, she mapped global protein expression changes during antimicrobial exposure, identified twenty-five citral-induced proteins, and revealed protein misfolding and aggregation mechanisms under oxidative stress. This work advanced the understanding of antifungal mechanisms of natural compounds and their potential translational applications in biofilm management and therapeutic development. Collectively, Dr. Chatrath’s research integrates advanced proteomics, protein biochemistry, and molecular microbiology to dissect microbial adaptation to stress and antimicrobial pressure, while providing new insights into cell wall biology, host–pathogen interactions, and antifungal discovery.

Areas of Interest
  • Bioactive peptides and proteins
  • Fungal biology
  • Proteomics
  • Genetics
  • Glycobiology
Publications
  • Apurva Chatrath, Pavan Patel, Protyusha Dey, Stephen J Free. Characterization of the Neurospora crassa GH72 family of Laminarin/Lichenin transferases and their roles in cell wall biogenesis. The Cell Surface, 2025, 100140. 
    https://doi.org/10.1016/j.tcsw.2024.100140
  • Apurva Chatrath, Protyusha Dey, Kevin Greeley, Gabriela Maciel, Lei Huang, Christian Heiss, Ian Black, Parastoo Azadi, Stephen J Free. Characterization of the Neurospora crassa Galactosaminogalactan Biosynthetic Pathway. Microorganisms, 2024, 12(8), 1509.
    http://doi.org/10.3390/microorganisms1208509
  • Apurva Chatrath, Manish Kumar, Ramasare Prasad. Comparative Proteomics and Variations in Extracellular Matrix of Candida tropicalis Biofilm in Response to Citral. Protoplasma, 2021, 259, 263-275. 
    https://doi.org/10.1007/s00709-021-01658-6
  • Apurva Chatrath, Rashmi Gangwar, Poonam Kumari, Ramasare Prasad. In vitro Anti-Biofilm Activities of Citral and Thymol against Candida tropicalis. Journal of Fungi, 2019, 5(1), 13. 
    https://doi.org/10.3390/jof5010013
  • Anchal Sharma, Vijay Kumar, Apurva Chatrath, Aditya Dev, Ramasare Prasad, Ashwani Kumar Sharma, Shailly Tomar and Pravindra Kumar. In vitro Metal Catalyzed Oxidative Stress in DAH7PS: Methionine Modification Leads to Structure Destabilization and Induce Amorphous Aggregation. International Journal of Biological Macromolecules, 2018, 106, 1089-1106. 
    https://doi.org/10.1016/j.ijbiomac.2017.08.105