Reema Gabrani, Professor, joined the institute in July 2004. She did her graduation in Human Biology and Masters in Biotechnology from All India Institute of Medical Sciences, New Delhi. She obtained her doctorate from National Institute of Immunology, New Delhi. She received DBT fellowship at Masters level and Qualified National Eligibility (NET) test conducted by CSIR-UGC and has been the recipient of CSIR junior and senior research fellowships for doctoral studies. She has done her post-doctoral research work in the area of Molecular Virology from University of Minnesota, USA.
Her major research areas are Molecular Virology and Therapeutic aspects of phytochemicals and peptides. Current research interests in molecular virology include the studies on emerging virus chikungunya virus which is responsible for annual large scale outbreaks in the country since 2006 when it infected ~1.6 million individuals. The on-going research objectives are to understand the molecular and cell biology of chikungunya virus- host interactions; decipher the possible role of host proteins in propagation of disease; identify interactions which could be target for therapeutics and identify peptide based inhibitors. Thus the studies on protein based interactions of chikungunya virus with viral and host factors will help in understanding the pathogenesis and disease progression and could provide leads for future interventions.
The emergence of multidrug resistance is a growing menace which needs to be addressed on urgent basis. Research interests also cover the anti-microbial aspects of plant active compounds & antimicrobial peptides and their nano-encapsulated forms to understand the scientific basis of their activity which could lead to the development of unique drugs. Moreover, cancer drug resistance is an enormous problem which is responsible for most relapses after initial successful remission. The current research work encompasses screening for synergistic combination of compounds against drug resistant glioblastoma cells. The selected combinations of compounds are being studied for their effectiveness in restricting cell survival, invasion and migration, the hallmark features of cancer.
She has several publications in high impact international journals and one Technology transfer to the industry.She was the convener for Faculty Development program on "Recent Advances in Diagnostics and therapeutics" from July 18-23, 2016. She co- organized DBT-sponsored one-day National conference on "Biodiversity and Agribiotechnology' on April 25, 2009 and five days Workshop on 'Plant Bio-products And Industrial Scale-Up' n collaboration with Sanat Products Ltd. from July 5-9, 2010 at JIIT, Noida.
Re-emerging Chikungunya virus (CHIKV) raises the alarming threat due its extensive global outbreak along with the unavailability of any antiviral therapy. The knowledge about the host proteins interacting with the CHIKV is very limiting. Elucidation of the viral-host protein interactions are indispensable for understanding the complete pathogenesis of CHIKV including hijacking of cellular machinery by CHIKV and directing it towards its replication. Positive host interactors after yeast two hybrid are identified by sequencing and validated by GST (glutathione S-transferase) pull down, ELISA and localization studies in mammalian cells. Proposed study will encompass the finding of potential anitiviral target sites which will further help in the development of antiviral molecule.
Another research focus is to explore the effective combination of drugs/ compounds for the treatment of Glioblastoma (GBM). GBM is the most aggressive and lethal brain cancer with poor outcome.Currently standard drug used to treat GBM is Temozolomide. There is no additional treatment strategy that can prolong the overall survival. Development of new treatment options that can improve survival of patients with GBM is needed. The combinatorial drug treatment can work by different molecular mechanisms and improve efficacy in restricting tumor growth and can also reduce the drug resistance problem. Moreover, the drugs in combination can have reduced toxicity.
G. Agarwal, R. Gabrani, “Identification of peptide binders to recombinant chikungunya virus envelope protein 2 using phage display technology and their in silico characterization” Protein PeptLett. 2020 Oct 29. doi: 10.2174/0929866527666201029144245. Online ahead of print. [IF: 1.2]
R. Ghildiyal, R. Gabrani, “Deciphering the human cellular interactors of alphavirus unique domain of Chikungunya Virus” Virus Res. Vol.295, pp. 198288.Jan 2021 doi: 10.1016/j.virusres.2020.198288. Online ahead of print.[IF: 3.0]
G. Agarwal,R. Gabrani, Antiviral Peptides: Identification and Validation. International Journal of Peptide research and therapeutics,May 18: 1-20. 2020. DOI: 10.1007/s10989-020-10072-0 [IF: 1.2] [Epub ahead of print]
- Kaur, R. Gabrani, S. Dang, “Antimicrobial activity of nanoemulsion encapsulated with polyphenon 60 and ciprofloxacin for the treatment of urinary tract infection” Advances in Traditional Medicine 2020 https://doi.org/10.1007/s13596-020-00483-1
- G. Sharma, S. Dang, Aruna K, M. Kalia, R. Gabrani, “Synergistic antibacterial and anti-biofilm activity of nisin like bacteriocin with curcumin and cinnamaldehyde against ESBL and MBL producing clinical strains” Biofouling, vol. 36(6), pp. 710-724, Jul 2020 DOI:10.1080/08927014.2020.1804553 [IF: 3.0]
- R. Ghildiyal, R. Gabrani, “Antiviral therapeutics for chikungunya virus” Expert OpinTher Pat, vol. 30, pp. 467-480, Jun 2020 DOI: 10.1080/13543776.2020.1751817[IF: 4.297]
- K. Nigam, R. Gabrani and S. Dang. “Nano-emulsion from Capsaicin: Formulation and Characterization” Materials Today: Proceedings, vol. 18, pp. 869-878, Aug 2019.
- G. Sharma, H. Gupta, S. Dang, S. Gupta, R. Gabrani, “Characterization of antimicrobial substance with antibiofilm activity from Pediococcusacidilactici” Journal of Microbiology, Biotechnology and Food Sciences,vol. 9 (5), pp. 979-982, April-May 2020[Scopus]
- I. Nandi, A. Gupta, VK. Chaudhary, V. Gupta, R. Gabrani*, S. Gupta*, “Expression, purification and functional characterization of recombinant Hyper Variable Region (HVR) of Chikungunya virus nsP3 protein” 3Biotech, vol. 9, pp. 235, June 2019. [IF: 1.8] * Corresponding author
- UL. Raj, M. Gautam, S. Dang, R. Gabrani, “Antibacterial and antibiofilm activities of trans-cinnamaldehydenanoemulsion against Escherichia coli” Asian J Pharm Clin Res, vol. 12, pp. 301-304, Feb. 2019.
- G. Agarwal, S. Gupta, R. Gabrani, A. Gupta, VK. Chaudhary, V. Gupta “Virtual screening of inhibitors against Envelope glycoprotein of Chikungunya Virus: a drug repositioning approach” Bioinformation, vol. 15(6), pp. 439-447, June 2019.
- R. Ghildiyal, S. Gupta, R. Gabrani, G. Joshi, A. Gupta, VK. Chaudhary, V. Gupta, “Chikungunya polymerase: a potential target for inhibitors—in silico study” Virus Diseasevol. 30(3), pp. 394-402, Sep. 2019.https://doi.org/10.1007/s13337-019-00547-0
- K. Nigam, A. Kaur, A. Tyagi, M. Nematullah, F. Khan, R. Gabrani, S. Dang, “Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles” Drug DelivTransl Res, vol. 9, pp. 879-890, Mar 2019. doi: 10.1007/s13346-019-00622-5.[IF: 3.111]
- K. Nigam, A. Kaur, A. Tyagi , K. Manda, R. Gabrani, S. Dang. Baclofen-Loaded Poly (d,l-Lactide-Co-Glycolic Acid) Nanoparticles for Neuropathic Pain Management: In Vitro and In Vivo Evaluation. Rejuvenation Res. Vol. 22(3), pp. 235-245. June 2019. [Impact factor 3.2]
- G. Sharma, S. Dang, S. Gupta, and R. Gabrani, "Antibacterial Activity, Cytotoxicity and Mechanism of Action of Bacteriocin from Bacillus subtilis GAS101".Med Princ Pract, 2018;27(2):186-192.[Impact factor: 1.5]
- A.Kaur, N. Kapoor, S.Gupta, A. Tyagi, R. K. Sharma, J.Ali, A. K. Panda, R. Gabrani, and S. Dang, Development and Characterization of Green Tea Catechin and Ciprofloxacin Loaded Nanoemulsion for Intravaginal Delivery to Treat Urinary Tract Infection", Indian journal of pharmaceutical sciences, 2018;80(3); 442-452. (Impact factor: 0.74)
- A. Kaur, S. Gupta, A. Tyagi, R. K. Sharma, J. Ali, R. Gabrani, and S. Dang Development of Nanoemulsion Based Gel Loaded with Phytoconstituents forthe Treatment of Urinary Tract Infection and in Vivo Biodistribution Studies. Adv Pharm Bull. 2017;7(4):611-619. [Scopus; IF=0.61]
- G. Sharma, K. Raturi, S. Dang, S. Gupta, and R. Gabrani, Inhibitory effect of cinnamaldehyde alone and in combination with thymol, eugenol and thymoquinone against Staphylococcus epidermidis.J Herbal Med, 2017; 9: 68-73[Impact factor: 1.3]
- G. Sharma, Dang, S. Gupta, and R. Gabrani, Identification and molecular characterization of bacteria having antimicrobial and antibiofilm activity. Int J Pharm Pharm Sci, 2016;8(10):111-114. [Indexed in scopus]
- L. Chakrawarti,R. Agrawal,S. Dang,S. Gupta, R. Gabrani. Therapeutic effects of EGCG: a patent review. Expert Opin Ther Pat.2016;26(8):907-16. [Impact factor: 4.297]
- G. Sharma, S. Sharma, P. Sharma, D. Chandola, S. Dang, S. Gupta, R. Gabrani. Escherichia coli biofilm: development and therapeutic strategies. J Appl Microbiol 2016;121:309-19. [Impact factor: 2.386]
- S. Agarwal,G. Sharma,S. Dang,S. Gupta,R. Gabrani. Antimicrobial Peptides as Anti-infectives against Staphylococcus epidermidis. Med Princ Pract;25:301-8, 2016. [Impact factor: 1.34]
- D. Sharma, G. Philip, R. Gabrani, J. Ali, S. Dang. "Dual agents loaded polymeric nanoparticle: Effect of process variables". Int J Pharma Investig, Vol 5(3), pp.155–160, 2015.
- N.P. Singh,A. Tiwari,A. Bansal,S. Thakur,G. Sharma,R. Gabrani. Genome level analysis of bacteriocins of lactic acid bacteria. Computational Biology and Chemistry, Vol. 56, pp. 1-6, 2015. [Impact factor:1.595]
- D. Sharma, R. K. Sharma, A. Bhatnagar, D. K. Nishad, T. Singh, R. Gabrani, S. K. Sharma, J. Ali, S. Dang, " Nose to brain delivery of midazolam loaded PLGA nanoparticle: in vitro and in vivo investigations". Current Drug Delivery 13(4):557-64, 2016. [Impact factor:2.2]
- D. Sharma, R.K. Sharma, N. Sharma, R. Gabrani, S.K. Sharma, J. Ali, S. Dang. Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles. AAPS PharmSciTech. 16(5):1108-21, 2015. [Impact factor:1.776]
- N. Dudha, J. Rana, S. Rajasekharan, R. Gabrani, A. Gupta, V.K. Chaudhary, S. Gupta. Host-pathogen interactome analysis of Chikungunya virus envelope proteins E1 and E2. Virus Genes, vol.50, pp.200-9, 2015 [Impact factor: 1.837]
- A. Bhaskar,K. Raturi,S. Dang,R. Gabrani. Current perspectives on the therapeutic aspects of chronic myelogenous leukemia. Expert Opinion on Therapeutic Patents,Vol. 24 pp. 1117-27, 2014. [Impact factor:3.4]
- D. Sharma, D. Maheshwari, G. Philip, R. Rana, S. Bhatia, M. Singh, R. Gabrani, S. Sharma, J. Ali, R. K. Sharma, S. Dang. Formulation and optimization of polymeric nanoparticles for intranasal delivery of lorazepam using box-behnken design: in vitro and in vivo evaluation. BioMed Research International, Vol. 2014, Article ID 156010, 2014. [Impact factor: 2.88]
- D. Sharma, R. Gabrani, S. k. Sharma, J. Ali, S. Dang. Development of Midazolam Loaded Poly(D, L-lactide-co-glycolic acid) Nanoparticlesfor Treatment of StatusEpilepticus. Advanced Science letters Vol. 20, No. 7-9, pp.1526-1530, 2014. [Impact factor: 1.2]
- S.Gupta, R.Bansal, D. Maheshwari, J. Ali, R. Gabrani, and S. Dang. Development of a nanoemulsion system for Polyphenon 60 and Cranberry. Advanced Science letters Vol. 20, No. 7-9, pp.1683-1686, 2014. [Impact factor: 1.2]
- S. Gupta, R. Bansal, J. Ali, R. Gabrani, and S. Dang, "Development and Characterization of Polyphenon 60 and Caffeine Microemulsion for Enhanced Antibacterial Activity" BioMed Research International, vol. 2014 (2014), Article ID 932017 [Impact factor: 2.88]
- G. Sharma, K. Raturi, S. Dang, S. Gupta, and R. Gabrani, "Combinatorial antimicrobial effect of curcumin with selected phytochemicals on Staphylococcus epidermidis" Journal of Asian Natural Products Research, vol. 16, No. 5. pp.535-541, 2014 [Indexed in SCOPUS, Impact factor:0.97]
- G. Sharma, S. Rao, A. Bansal, S. Dang, S.Gupta, and R. Gabrani, "Pseudomonas aeruginosa biofilm: Potential therapeutic targets" Biologicals, vol. 42, No. 1. pp. 1-7, 2014. [Indexed in SCOPUS, Impact factor: 1.6]
- P. Kaushik, C. K. Jain, R. Gabrani, and T. R. Singh, "Study on variability assessment and evolutionary relationships of glutamate racemase in Pseudomonas species," Interdisciplinary Sciences: Computational Life Sciences, vol. 5, No. 4. pp. 247-257, 2013. [Indexed in scopus]
- K. Kumar, S. Rajasekharan, S. Gulati, J. Rana, R. Gabrani, C. K. Jain, A. Gupta, V. K. Chaudhary, and S. Gupta, "Elucidating the interacting domains of chandipura virus nucleocapsid protein" Advances in Virology vol. 2013, pp. 594319, 2013 [Indexed in SCOPUS, Impact factor: 1.1]
- C. K. Jain,A.Dasgupta, N. Taneja, S. Chaubey,R. Gabrani, S. K. Sharma and S. Gupta,"Putative drug targets inRhizopus oryzae: in-silicoinsight"International Journal of Bioinformatics and Applications,vol. 9, No. 6, pp. 595-603, 2013.[Indexed in SCOPUS]
- N. Panjiar,R. Gabraniand I.P. Sarethy. "Diversity of biosurfactant-producingStreptomycesisolates from hydrocarbon-contaminated soil".International Journal of Pharma and Bio Sciences,vol. 4, No. 1, pp 524-535, Jan 2013.[Indexed in SCOPUS, Impact Factor 0.4]
- R. Gabrani,R. Jain, A. Sharma, I.P. Sarethy, S. Dang and S. Gupta "Antiproliferative Effect ofSolanum nigrumon Human Leukemic Cell Lines"Indian Journal of Pharmaceutical Sciences vol. 74, pp. 451-453, Sep. 2012.[Indexed in SCOPUS, Impact factor:0.626]
- R. Sreejith, J. Rana, N. Dudha, K. Kumar,R. Gabrani, S. K. Sharma, A. Gupta, S. Vrati, V. K. Chaudhary and S. Gupta,"Mapping of interactions among Chikungunya virus nonstructural proteins"Virus Research,vol. 169, pp. 231-6, Oct. 2012.[Indexed in SCOPUS, Impact factor:3]
- S. Gupta, N. Dudha, M. B. Appaiahgari, K. Bharati, D. Gupta, Y. Gupta, K. Kumar,R. Gabrani, S. K. Sharma, A. Gupta, V. K. Chaudhary and S. Vrati,"Molecular cloning and characterization of Chikungunya virus genes from Indian isolate of 2006 outbreak"Journal of Pharmacy Research,vol. 5, pp. 3860-3863, Aug. 2012.[Indexed in DOAJ]
- K. Kumar, J. Rana, R. Sreejith,R. Gabrani, S. K. Sharma, A. Gupta, V. K. Chaudhary and S. Gupta,"Intraviral protein interactions of Chandipura Virus"Archives of Virology,vol.157, pp. 1949-1957, Oct. 2012.[Indexed in SCOPUS, Impact factor:2.1]
- S. Gupta, J.K. Sahni, J. Ali,R. Gabraniand S. Dang, "Development and Characterization of Green Tea Loaded Microemulsion for Vaginal Infections",Advanced Material letters,vol. 3, pp. 493-497, Dec. 2012.[Indexed in SCOPUS]
- A. Sharma, S.Gupta, I.P. Sarethy, S. Dang, andR. Gabrani, "Green tea extract: possible mechanism and antibacterial activity on skin pathogens"Food Chemistry,vol. 135, pp. 672-675, Nov. 2012.[Indexed in SCOPUS, Impact factor: 3.655]
- A. Agrawal,S. DangandR. Gabrani, "Recent Patents on Anti-Telomerase Cancer Therapy".Recent Patents on Anticancer Drug Discovery,vol. 7, pp. 102-17, Jan 2012.[Indexed in SCOPUS, Impact factor: 2.82]
- K. Banerjee, U. Gupta, S.Gupta, G.Wadhwa,R. Gabrani, S. K. Sharma and C. K. Jain,"Molecular docking of glucosamine-6-phosphate synthase inRhizopus oryzae".Bioinformation,vol. 7, pp. 285-290, Nov. 2011.[Indexed in PUBMED, Impact factor:1.15]
- U. Gupta, K. Banerjee,R. Gabrani, S. Gupta, S. K. Sharma and C. K. Jain, "Variability analyses of functional domains within glucosamine-6-phosphate synthase of mycoses-causing fungi"Bioinformation,vol. 6, pp. 196-199, May 2011.[Indexed in Pubmed, Impact factor:1.15]
- S. Gupta,R. Gabrani,J. Ali and S. Dang, "Exploring Novel Approaches to Vaginal Drug Delivery".Recent Patents on Drug delivery and Formulations, vol. 5, pp. 82-94, May 2011.[Indexed in SCOPUS]
- R. Jain, A. Sharma, S. Gupta, I.P. Sarethy andR. Gabrani, "Solanum nigrum: Current perspectives on therapeutic properties".Alternative Medicine Review,vol. 16, pp. 78-85, Mar 2011. [Indexed in SCOPUS, Impact factor: 3.52]
- I.P. Sarethy, N. Gulati, A. Bansal, V. Gupta, K. Malhotra andR. Gabrani, "Genetic structure of an endangered Cycas revoluta using RAPD markers".Research Journal of Biotechnology,Vol. 6, pp. 50-55, Feb. 2011[Indexed in SCOPUS]
- N. Shanker, N. Vikram, A. Tyagi,R. Gabrani, and I.P. Sarethy,"Study of Streptomyces diversity in arid and semi-arid soil of India".Journal of Pure & Applied Microbiology,vol. 4, pp. 687-699, Oct 2010.[Indexed in SCOPUS]
- A. K. Patra, R.Mukhopadhyay, R. Mukhija,A. Krishnan, L. C. Garg, and A. K. Panda, "Optimization of inclusion body solubilization and renaturation of recombinant human growth hormone fromEscherichia coli",Protein Expression and Puriication,vol. 18, pp. 182-192, Mar 2000.[Indexed in SCOPUS, Impact factor: 1.621]
- R. Mukhijaand L. C. Garg "N-terminus of mature heat-labile enterotoxin chain B is critical for its extracellular secretion inVibrio cholerae",FEBS Letters, vol. 463, pp. 336-340, Dec 1999.[Indexed in SCOPUS, Impact factor: 3.264]
- L.C. Garg, R. Mukhija, P. Das, G. Tiwari, A.K. Panda, P. Rupa "High level expression and single step purification of the 3-subunit of human chorionic gonadotrophin in E. coli and its immunogenicity in rats" FASEB Journal, vol. 11(9):A1204, 1997.[Indexed in SCOPUS, Impact factor: 5.48]
- R. Mukhija,P. Rupa, D. Pillai, and L. C. Garg, "High-level production and one-step purification of biologically active human growth hormone inEscherichia coli",Gene, vol. 165, pp. 303-306, Nov 1995.[Indexed in SCOPUS, Impact factor: 2.578]
SPONSORED R&D PROJECTS
- Analysis of host interactors of Chikungunya virus non structural Protein 1. CSIR; Rs. 7.12 Lakhs, Supervisor: Reema Gabrani; CSIR-SRF: R. Ghildiyal (2019-2021)
- Identification of cellular targets of chikungunya virus non structural proteins: Indian Council of Medical Research (ICMR), Govt. of India; Grant value: Rs. 34.1 Lakhs, PI: Sanjay Gupta; co-I:Reema Gabrani; (2016-2019).
- Development and evaluation of green tea catechins based intravaginal nanoemulsion gel for the treatment of urinary tract infections: Department of Biotechnology (DBT), Govt. of India, Grant value: Rs.23.35 lakhs, PI: Shweta Dang; co-I: Javed Ali, co-I:Reema Gabrani; (2013-2016).
- Viral-viral and viral-host protein interactions in Chandipura virus mediated encephalitis: Department of Science and Technology (DST), Govt. of India, Grant value:Rs. 35.6 Lakhs,PI: Sanjay Gupta; co-I:Amita Gupta; co-I:Reema Gabrani(2010-2013).
- Mapping of the interactions among Chikungunya virus proteins (CHIKV viral-viral interactions): Department of Biotechnology (DBT), Govt. of India, Grant value: Rs.24.869 Lakhs, PI: Sanjay Gupta;co-I:Reema Gabrani;co-I:Prof. V.K. Chaudhary (2008-2012).
- G. Sharma, N.P. Singh, A. Tiwari, S. Gupta and R. Gabrani,Lactococcus lactis16S ribosomal RNA gene, partial sequence. Genbank Accession No.KP671842, 2015.
- G. Sharma, N.P. Singh, A. Tiwari, S. Gupta and R. Gabrani, Pediococcus acidolacti16S ribosomal RNA gene, partial sequence. Genbank Accession No. KP671843, 2015.
- G. Sharma, S. Gupta and R. Gabrani, Bacillus subtilisstrain GAS101 16S ribosomal RNA gene, partial sequence. Genbank Accession No. KJ564301, 2014. S. Gupta, N. Dudha, K. Kumar, R. Gabrani, S.K. Sharma, A. Gupta, and V. K. Chaudhary, Submitted following Genbank SUBMISSIONS:
- Full-length cloned sequence of the non-structural protein 1 (nsP1) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272473, Jan. 31, 2011.
- Full-length cloned sequence of the non-structural protein 2 (nsP2)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272474, Jan. 31, 2011.
- Full-length cloned sequence of the non-structural protein 3 (nsP3)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272475, Jan. 31, 2011.
- Full-length cloned sequence of the non-structural protein 4 (nsP4)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272476, Jan. 31, 2011.
- Full-length cloned sequence of the capsid protein gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272477, Jan. 31, 2011.
- Full-length cloned sequence of the Envelope protein 3 (E3) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272478, Jan. 31, 2011.
- Full-length cloned sequence of the Envelope protein 2 (E2) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272479, Jan. 31, 2011.
- Full-length cloned sequence of the Envelope protein 1 (E1) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272480, Jan. 31, 2011.
- Full-length cloned sequence of the 6K gene of Chikungunya virus,isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272481, Jan. 31, 2011.
- I.P. Sarethy, N. Panjiar, and R. Gabrani, 16S rDNA sequence of Streptomyces isolate PN-18, capable of producing biosurfactant on complex carbon substrates. Accession no. GQ856644, Sep.29, 2009.
- I.P. Sarethy, N. Shanker, N. Vikram, A. Tyagi, and R. Gabrani, 16S rDNA sequence of Streptomyces isolate B-14, capable of growing on complex carbon substrates. Accession no. GQ426322, Sep.1, 2009.
R. Mukhija, A. K. Panda, L. C. Garg, (2010) Successful Technology Transfer of vector for human growth hormone to Indian Immunologicals Ltd. (National Institute of Immunology).
- Indian Patent Application No. 201911047575 dated 21st November, 2019. titled “Synergistic effect of temozolomide and phytocompound in human glioblastoma multiforme cell lines” in the name of Jaypee Institute of Information Technology, Inventors: M. Gautam, R. Gabrani
- Indian Patent Application No.: 202111001763 dated 14.01.2021. titled “Synergistic combination of temozolomide and d-limonene for glioblastomamultiforme treatment”Applicant:Jaypee Institute of Information Technology, Inventors: R. Gabrani, M. Gautam
- K. Nigam, P.H.Ruba, P.Kapoor, R. Gabrani, S.Dang, Nano-carriers for Natural Therapeutics in Management of Neuropathic Pain. In: Talegaonkar S., Rai M. (eds) Nanoformulations in Human Health. pp. 361-376, 2020 Springer, Cham. https://doi.org/10.1007/978-3-030-41858-8_16(Springer Nature Switzerland AG 2020)
- A. Kaur, R. Bansal, S. Gupta, R. Gabrani, and S. Dang, “Nanoemulsions: Status in Antimicrobial Therapy” In “Smart healthcare system”, Eds. M. Rathi, A. Sinha: Taylor and Francis CRC press, ISBN: 978-0-367-03000-1 Chapter 6, 83-107, 2019
- R. Ghildiyal, V. Prakash, V.K. Chaudhary, V.Gupta, R. Gabrani "Phytochemicals as Antiviral Agents: Recent Updates" In “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” Ed. M. K. Swamy, Vol 2 12 May 2020;279‐295. doi:10.1007/978-981-15-1761-7_12 Springer ISBN 978-981-15-1761-7 (eBook)
- G. Maheshwari, B.P. Chauhan, S. Dang, and R. Gabrani, “Treatment of Lung Cancer in the New Era” In“Frontiers in Anti-Cancer Drug Discovery” Eds. Atta-ur-Rahman and M.I. Choudhary, Bentham Science Publishers, 2019, chapter 4, Vol. 11, pp 101-116. ISBN: 978-981-14-2212-6
- R. Gabrani, R. Ghildiyal, N. Pratap, G. Sharma, S. Dang, “The applications of protein nanoparticles as drug delivery vehicle” In “Smart Healthcare Systems” Eds. M. Rathi, A. Sinha: Taylor and Francis (CRC Press). ISBN: 978-0-367-03000-1, chapter 13, 199-215 2019
- M. Gautam, S. Srivastav, N. Tiwary, S. Dang, R. Gabrani."Phytotherapeutics: The Substitutes for Glioblastoma Multiforme" In"Natural Bioactive compounds: Production and Applications". Eds: M. S. Akhtar and M. K. Swamy, Springer Nature Singapore Pte Ltd., Singapore 2019, Vol. 2, chapter 9, pp. 201-214.
- M. Gautam, S. Singh, M. Aggarwal, MK. Sharma, S. Dang, R. Gabrani "Glioblastoma Multiforme; Drug Resistance & Combination Therapy" In "Frontiers in Anti-Cancer Drug Discovery" Eds. Atta-ur-Rahman and M.I. Choudhary, Bentham Science Publishers, 2019, chapter 5, Vol. 10, pp 111-130. ISBN:978-981-14-0191-6
- S. Srivastava,G. Jain, S. Dang, S. Gupta and R. Gabrani, "Phytochemicals Targeting ER Stress to Inhibit Cancer Cell Proliferation" In "Anticancer Plants: Natural Products and Biotechnological Implements"Editors: M. S. Akhtar and M. K. Swamy; Springer, 2018, Vol. 2, chapter 12, pp. 273-287. ISBN:978-981-10-8063-0.
- G.Gaur, U.L. Raj, S.Dang, S.Gupta,R.Gabrani"Plant-derived Drug Molecules as Antibacterial Agents" In "Functional Food and Human Health" Ed. V. Rani and U.C.S. Yadav; Springer, 2018
- U. L. Raj, G. Sharma, S. Dang, S. Gupta, R. Gabrani "Impact of Dietary Supplements on Skin Aging" In "Textbook of Aging Skin" 2nd Ed. M.A. Farage, K.W. Miller, H.I. Maibach; Springer, ISBN:978-3-642-27814-3, 2017.
- A. Agrawal, S. Dang and R. Gabrani "Recent Advances in Anti-Telomerase Cancer Therapy" In "Topics in Anti-Cancer Research" Volume 3, Ed Atta-ur-Rahman and K. Zaman; Bentham Science Publishers, 2014, chapter 16, pp. 581-631.
- R. Gabrani, G. Sharma, S. Dang, S. Gupta "Role of ROS in bacterial resistance and biofilm formation and possible therapeutics" In "Free Radicals in Human Health & Diseases" Ed. V. Rani and U.C.S. Yadav; Springer, 2014, chapter 23, pp. 369-379.
- S. Dang, S. Gupta, R. Bansal, J. Ali and R. Gabrani "Nano encapsulation of Green Tea Catechins – key to preserve its anti-oxidative potential" In "Free Radicals in Human Health & Diseases" Springer, 2014, chapter 25, pp. 397-415.
- R. Gabrani. "Cancer biology and RNAi" in Modern Biotechnology and its applications Part 2. Kambaska Behera, Ed. New India Publication Agency, N. Delhi, India. 2013, pp. 513-542.
- Atinderpal Kaur (2020): Development of Drug Loaded Nanoemulsion Based Formulations for Urinary Tract Infection. (as Co-PI)
- Garima Sharma (2017): Purification, characterization and antibacterial studies of bacteriocins from dairy farm isolates. (as PI)
- Sonal Gupta (2015): Development of Nano-Carrier Based Antibacterial Formulation of Green Tea and Synergistic Phytochemicals. (as Co-PI)
- Namrata Dudha (2015) Topic: Mapping interactions of Chikungunya Virus structural Proteins. (as Co-PI)
- Kapila Mehta (2013) Topic: Intraviral Protein Interactions of Chandipura Virus. (as Co-PI)