Jaypee Institute of Information Technology, Noida
  • JIIT
  • JIIT
  • JIIT
  • JIIT
Professor
reema.gabrani@jiit.ac.in

BIOGRAPHY

Reema Gabrani, Professor, joined the institute in July 2004. She did her graduation in Human Biology and Masters in Biotechnology from All India Institute of Medical Sciences, New Delhi. She obtained her doctorate from National Institute of Immunology, New Delhi. She received DBT fellowship at Masters level and Qualified National Eligibility (NET) test conducted by CSIR-UGC and has been the recipient of CSIR junior and senior research fellowships for doctoral studies. She has done her post-doctoral research work in the area of Molecular Virology from University of Minnesota, USA.

She has several publications in high impact international journals, two patents and one Technology transfer to the industry.She was the convener for Faculty Development program on "Recent Advances in Diagnostics and therapeutics" from July 18-23, 2016. 

RESEARCH HIGHLIGHTS

Current research interests in molecular virology include the studies on emerging virus chikungunya virus (CHIKV), which is responsible for annual large-scale outbreaks in the country since 2006 when it infected ~1.6 million individuals. Re-emerging CHIKV raises an alarming threat due to its extensive global outbreak along with the unavailability of any antiviral therapy. The knowledge about the host proteins interacting with the CHIKV is very limited. Elucidation of the viral-host protein interactions is indispensable for understanding the complete pathogenesis of CHIKV including the hijacking of cellular machinery by CHIKV and directing it toward its replication. The ongoing research objectives are to understand the molecular and cell biology of CHIKV- host interactions; decipher the possible role of host proteins in the propagation of disease; identify interactions that could be targets for therapeutics and identify peptide-based inhibitors. Thus the studies on protein-based interactions of CHIKV with viral and host factors will help in understanding the pathogenesis and disease progression and could provide leads for future interventions.

The emergence of multidrug resistance is a growing menace, which needs to be addressed on an urgent basis. Research interests also cover the anti-microbial aspects of plant active compounds & antimicrobial peptides and their nano-encapsulated forms to understand the scientific basis of their activity, which could lead to the development of unique drugs.

Moreover, cancer drug resistance is an enormous problem responsible for most relapses after initial successful remission. Another research focus is to explore the effective combination of drugs/ compounds for the treatment of Glioblastoma (GBM). GBM is the most aggressive and lethal brain cancer with poor outcomes. Currently, standard drug used to treat GBM is temozolomide. There is no additional treatment strategy that can prolong the overall survival. Development of new treatment options that can improve the survival of patients with GBM is needed. The combinatorial drug treatment can work by different molecular mechanisms and improve efficacy in restricting tumor growth and can also reduce the drug resistance problem. Moreover, the drugs in combination can have reduced toxicity.

GRANTED PATENT

  • Indian Patent titled “Synergistic combination of temozolomide and d-limonene for glioblastoma multiforme treatment” Patent No.: 501913, The Indian Patent Office. Date of Grant: 22/01/2024. Inventors: M. Gautam, R. Gabrani.
  • Indian Patent titled “Synergistic effect of temozolomide and phytocompound in human glioblastoma multiforme cell lines” Patent No.: 424890, The Indian Patent Office. Date of Grant: 13/03/2023. Inventors: M. Gautam, R. Gabrani.

PUBLICATIONS

  • M. Gautam, and R. Gabrani, “Synergism of d-limonene and temozolomide on migratory and apoptotic behaviors of human Glioblastoma cell lines”, Bioimpacts, Vol. 14(5), pp. 27681, January 2024 [IF: 4.0, SCOPUS, SCI]

  • M. Gautam and R. Gabrani, “Evaluation of the vanillin treatment on migration and anchorage-independent growth of glioblastoma cell line,” Journal of Applied Biology and Biotechnology, Volume 12, Issue 1, January, 2024 [IF: 1.0, SCOPUS]

  • U. Naithani, P. Jain, A. Sachan, P. Khare, R. Gabrani, “MicroRNA as a potential biomarker for systemic lupus erythematosus: pathogenesis and targeted therapy”, Clinical and Experimental Medicine, Vol:23(8), pp. 4065-4077, Dec, 2023. [IF: 4.6, SCOPUS, SCI 

  • V. Prakash, R. Gabrani, An Insight into Emerging Phytocompounds for Glioblastoma Multiforme Therapy, Cardiovasc Hematol Agents Med Chem. Nov, 2023. Online ahead of print. [IF: 1.5, SCOPUS]

  • M. Gautam, R. Gabrani, “Evaluation of bromelain and temozolomide synergistic combination in human glioblastoma cells” Adv Tradit Med (ADTM), Oct 2023. https://doi.org/10.1007/s13596-023-00717-y[IF: 2.0, SCOPUS]

  • M. Gautam, R. Gabrani, “Comparative analysis of α-pinene alone and combined with temozolomide in human glioblastoma cells”, Nat Prod Res. Sep 4:1-6. 2023, doi: 10.1080/14786419.2023.2252152. Online ahead of print. [IF 2.5, Scopus, SCI]

  • M. Gautam, R. Gabrani, “Systematic Illustration of the Plant-Derived Compounds via Bioinformatics Tools” International Journal of All Research Education and Scientific Methods (IJARESM), Vol. 11(6), pp. 2522-2527, June 2023.

  • M. Gautam, R. Gabrani. “Combinatorial Effect of Temozolomide and Naringenin in Human Glioblastoma Multiforme Cell Lines”. Nutr Cancer, vol. 74(3), pp. 1071-1078, 2022. doi: 10.1080/01635581.2021.1952438. [IF 2.32]
  • K. Nigam, Md. Nematullah, F. Khan, R. Gabrani, S. Dang Title: In-vitro investigations of Baclofen loaded PLGA nanoparticles, Nanotechnology PERCEPTIONS Vol. 18, pp 46–52, Oct 2022, doi: 10.4024/N26NI19A.ntp.18.01
  • S. Maurya, R. Gabrani, “Glioblastoma and its Complications” VSRD International Journal of Bio-Technology & Pharmaceutical Sciences, Special Issue on: Biomedical Sciences and Computational Biology. Vol. XI, pp. 62-66, August 2022 ISSN: 2278-9197
  • P. Bhatia, R. Gabrani, “Mouse Models for Understanding Glioblastoma Multiforme” VSRD International Journal of Bio-Technology & Pharmaceutical Sciences, Special Issue on: Biomedical Sciences and Computational Biology. Vol. XI, pp. 30-34, August 2022 ISSN: 2278-9197
  • Nigam K, Kaur A, Tyagi A, Manda K, Goswami N, Nematullah M, Khan F, Gabrani R, Gauba P, Dang S. In vitro & in vivo evaluations of PLGA nanoparticle based combinatorial drug therapy for baclofen and lamotrigine for neuropathic pain management. J Microencapsul. Vol. 39(2), pp. 95-109, Mar 2022 doi: 10.1080/02652048.2022.2041751.
  • Prakash, V. & Gabrani, R.  (2022). Effect of Natural Compounds on Glioblastoma Multiforme Pathways. Curr Trends Biotechnol Pharm., Vol. 15(6), pp. 9–27. Jan 2022 https://doi.org/10.5530/ctbp.2021.6.5 
  • R. Ghildiyal, R. Gabrani, “Computational Analysis of Human Host Binding Partners of Chikungunya and Dengue Viruses during Coinfection” Pathog Dis. Vol. 79(8), pp. ftab046, 2021. doi: 10.1093/femspd/ftab046. [IF:  3.16]
  • R. Ghildiyal, R. Gabrani, “Computational approach to decipher cellular interactors and drug targets during co-infection of SARS-CoV-2, Dengue, and Chikungunya virus”. VirusDisease, vol. 32(1), pp.55-64, Mar. 2021.  https://doi.org/10.1007/s13337-019-00547-0 [IF:  1.29]
  • G. Agarwal, R. Gabrani, “Identification of peptide binders to recombinant chikungunya virus envelope protein 2 using phage display technology and their in silico characterization” Protein PeptLett. 2020 Oct 29.Vol. 28(5), pp.508-519. 2021 doi: 10.2174/0929866527666201029144245. Online ahead of print. [IF: 1.2]

  • R. Ghildiyal, R. Gabrani, “Deciphering the human cellular interactors of alphavirus unique domain of Chikungunya Virus” Virus Res. Vol.295, pp. 198288.Jan 2021 doi: 10.1016/j.virusres.2020.198288. Online ahead of print.[IF: 3.0]

  • G. Agarwal,R. Gabrani, Antiviral Peptides: Identification and Validation. International Journal of Peptide research and therapeutics,May 18: 1-20. 2020. DOI: 10.1007/s10989-020-10072-0 [IF: 1.2] [Epub ahead of print]

  • Kaur, R. Gabrani, S. Dang, “Antimicrobial activity of nanoemulsion encapsulated with polyphenon 60 and ciprofloxacin for the treatment of urinary tract infection” Advances in Traditional Medicine 2020 https://doi.org/10.1007/s13596-020-00483-1
  • G. Sharma, S. Dang, Aruna K, M. Kalia, R. Gabrani, “Synergistic antibacterial and anti-biofilm activity of nisin like bacteriocin with curcumin and cinnamaldehyde against ESBL and MBL producing clinical strains” Biofouling, vol. 36(6), pp. 710-724, Jul 2020 DOI:10.1080/08927014.2020.1804553 [IF: 3.0]
  • R. Ghildiyal, R. Gabrani, “Antiviral therapeutics for chikungunya virus” Expert OpinTher Pat, vol. 30, pp. 467-480, Jun 2020 DOI: 10.1080/13543776.2020.1751817[IF: 4.297]
  • K. Nigam, R. Gabrani and S. Dang. “Nano-emulsion from Capsaicin: Formulation and Characterization” Materials Today: Proceedings, vol. 18, pp. 869-878, Aug 2019. 
  • G. Sharma, H. Gupta, S. Dang, S. Gupta, R. Gabrani, “Characterization of antimicrobial substance with antibiofilm activity from PediococcusacidilacticiJournal of Microbiology, Biotechnology and Food Sciences,vol. 9 (5), pp. 979-982, April-May 2020[Scopus]
  • I. Nandi, A. Gupta, VK. Chaudhary, V. Gupta, R. Gabrani*, S. Gupta*, “Expression, purification and functional characterization of recombinant Hyper Variable Region (HVR) of Chikungunya virus nsP3 protein” 3Biotech, vol. 9, pp. 235, June 2019. [IF: 1.8] * Corresponding author
  • UL. Raj, M. Gautam, S. Dang, R. Gabrani, “Antibacterial and antibiofilm activities of trans-cinnamaldehydenanoemulsion against Escherichia coli” Asian J Pharm Clin Res, vol. 12, pp. 301-304, Feb. 2019. 
  • G. Agarwal, S. Gupta, R. Gabrani, A. Gupta, VK. Chaudhary, V. Gupta “Virtual screening of inhibitors against Envelope glycoprotein of Chikungunya Virus: a drug repositioning approach” Bioinformation, vol. 15(6), pp. 439-447, June 2019.
  • R. Ghildiyal, S. Gupta, R. Gabrani, G. Joshi, A. Gupta, VK. Chaudhary, V. Gupta, “Chikungunya polymerase: a potential target for inhibitors—in silico study” Virus Diseasevol.  30(3), pp. 394-402, Sep. 2019.https://doi.org/10.1007/s13337-019-00547-0
  • K. Nigam, A. Kaur, A. Tyagi, M. Nematullah, F. Khan, R. Gabrani, S. Dang, “Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles” Drug DelivTransl Res, vol. 9, pp. 879-890, Mar 2019. doi: 10.1007/s13346-019-00622-5.[IF: 3.111] 
  • K. Nigam, A. Kaur, A. Tyagi , K. Manda, R. Gabrani, S. Dang. Baclofen-Loaded Poly (d,l-Lactide-Co-Glycolic Acid) Nanoparticles for Neuropathic Pain Management: In Vitro and In Vivo Evaluation. Rejuvenation Res. Vol. 22(3), pp. 235-245. June 2019. [Impact factor 3.2]
  • G. Sharma, S. Dang, S. Gupta, and R. Gabrani, "Antibacterial Activity, Cytotoxicity and Mechanism of Action of Bacteriocin from Bacillus subtilis GAS101".Med Princ Pract, 2018;27(2):186-192.[Impact factor: 1.5]
  • A.Kaur, N. Kapoor, S.Gupta, A. Tyagi, R. K. Sharma, J.Ali, A. K. Panda, R. Gabrani, and S. Dang, Development and Characterization of Green Tea Catechin and Ciprofloxacin Loaded Nanoemulsion for Intravaginal Delivery to Treat Urinary Tract Infection", Indian journal of pharmaceutical sciences, 2018;80(3); 442-452. (Impact factor: 0.74)
  • A. Kaur, S. Gupta, A. Tyagi, R. K. Sharma, J. Ali, R. Gabrani, and S. Dang Development of Nanoemulsion Based Gel Loaded with Phytoconstituents forthe Treatment of Urinary Tract Infection and in Vivo Biodistribution Studies. Adv Pharm Bull. 2017;7(4):611-619. [Scopus; IF=0.61]
  • G. Sharma, K. Raturi, S. Dang, S. Gupta, and R. Gabrani, Inhibitory effect of cinnamaldehyde alone and in combination with thymol, eugenol and thymoquinone against Staphylococcus epidermidis.J Herbal Med, 2017; 9: 68-73[Impact factor: 1.3]
  • G. Sharma, Dang, S. Gupta, and R. Gabrani, Identification and molecular characterization of bacteria having antimicrobial and antibiofilm activity. Int J Pharm Pharm Sci, 2016;8(10):111-114. [Indexed in scopus]
  • L. Chakrawarti,R. Agrawal,S. Dang,S. Gupta, R. Gabrani. Therapeutic effects of EGCG: a patent review. Expert Opin Ther Pat.2016;26(8):907-16. [Impact factor: 4.297]
  • G. Sharma, S. Sharma, P. Sharma, D. Chandola, S. Dang, S. Gupta, R. Gabrani. Escherichia coli biofilm: development and therapeutic strategies. J Appl Microbiol 2016;121:309-19. [Impact factor: 2.386]
  • S. Agarwal,G. Sharma,S. Dang,S. Gupta,R. Gabrani. Antimicrobial Peptides as Anti-infectives against Staphylococcus epidermidis. Med Princ Pract;25:301-8, 2016. [Impact factor: 1.34]
  • D. Sharma, G. Philip, R. Gabrani, J. Ali, S. Dang. "Dual agents loaded polymeric nanoparticle: Effect of process variables". Int J Pharma Investig, Vol 5(3), pp.155–160, 2015.
  • N.P. Singh,A. Tiwari,A. Bansal,S. Thakur,G. Sharma,R. Gabrani. Genome level analysis of bacteriocins of lactic acid bacteria. Computational Biology and Chemistry, Vol. 56, pp. 1-6, 2015. [Impact factor:1.595]
  • D. Sharma, R. K. Sharma, A. Bhatnagar, D. K. Nishad, T. Singh, R. Gabrani, S. K. Sharma, J. Ali, S. Dang, " Nose to brain delivery of midazolam loaded PLGA nanoparticle: in vitro and in vivo investigations". Current Drug Delivery 13(4):557-64, 2016. [Impact factor:2.2]
  • D. Sharma, R.K. Sharma, N. Sharma, R. Gabrani, S.K. Sharma, J. Ali, S. Dang. Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles. AAPS PharmSciTech. 16(5):1108-21, 2015. [Impact factor:1.776]
  • N. Dudha, J. Rana, S. Rajasekharan, R. Gabrani, A. Gupta, V.K. Chaudhary, S. Gupta. Host-pathogen interactome analysis of Chikungunya virus envelope proteins E1 and E2. Virus Genes, vol.50, pp.200-9, 2015 [Impact factor: 1.837]
  • A. Bhaskar,K. Raturi,S. Dang,R. Gabrani. Current perspectives on the therapeutic aspects of chronic myelogenous leukemia. Expert Opinion on Therapeutic Patents,Vol. 24 pp. 1117-27, 2014. [Impact factor:3.4]
  • D. Sharma, D. Maheshwari, G. Philip, R. Rana, S. Bhatia, M. Singh, R. Gabrani, S. Sharma, J. Ali, R. K. Sharma, S. Dang. Formulation and optimization of polymeric nanoparticles for intranasal delivery of lorazepam using box-behnken design: in vitro and in vivo evaluation. BioMed Research International, Vol. 2014, Article ID 156010, 2014. [Impact factor: 2.88]
  • D. Sharma, R. Gabrani, S. k. Sharma, J. Ali, S. Dang. Development of Midazolam Loaded Poly(D, L-lactide-co-glycolic acid) Nanoparticlesfor Treatment of StatusEpilepticus. Advanced Science letters Vol. 20, No. 7-9, pp.1526-1530, 2014. [Impact factor: 1.2]
  • S.Gupta, R.Bansal, D. Maheshwari, J. Ali, R. Gabrani, and S. Dang. Development of a nanoemulsion system for Polyphenon 60 and Cranberry. Advanced Science letters Vol. 20, No. 7-9, pp.1683-1686, 2014. [Impact factor: 1.2]
  • S. Gupta, R. Bansal, J. Ali, R. Gabrani, and S. Dang, "Development and Characterization of Polyphenon 60 and Caffeine Microemulsion for Enhanced Antibacterial Activity" BioMed Research International, vol. 2014 (2014), Article ID 932017 [Impact factor: 2.88]
  • G. Sharma, K. Raturi, S. Dang, S. Gupta, and R. Gabrani, "Combinatorial antimicrobial effect of curcumin with selected phytochemicals on Staphylococcus epidermidis" Journal of Asian Natural Products Research, vol. 16, No. 5. pp.535-541, 2014 [Indexed in SCOPUS, Impact factor:0.97]
  • G. Sharma, S. Rao, A. Bansal, S. Dang, S.Gupta, and R. Gabrani, "Pseudomonas aeruginosa biofilm: Potential therapeutic targets" Biologicals, vol. 42, No. 1. pp. 1-7, 2014. [Indexed in SCOPUS, Impact factor: 1.6]
  • P. Kaushik, C. K. Jain, R. Gabrani, and T. R. Singh, "Study on variability assessment and evolutionary relationships of glutamate racemase in Pseudomonas species," Interdisciplinary Sciences: Computational Life Sciences, vol. 5, No. 4. pp. 247-257, 2013. [Indexed in scopus]
  • K. Kumar, S. Rajasekharan, S. Gulati, J. Rana, R. Gabrani, C. K. Jain, A. Gupta, V. K. Chaudhary, and S. Gupta, "Elucidating the interacting domains of chandipura virus nucleocapsid protein" Advances in Virology vol. 2013, pp. 594319, 2013 [Indexed in SCOPUS, Impact factor: 1.1]
  • C. K. Jain,A.Dasgupta, N. Taneja, S. Chaubey,R. Gabrani, S. K. Sharma and S. Gupta,"Putative drug targets inRhizopus oryzae: in-silicoinsight"International Journal of Bioinformatics and Applications,vol. 9, No. 6, pp. 595-603, 2013.[Indexed in SCOPUS]
  • N. Panjiar,R. Gabraniand I.P. Sarethy. "Diversity of biosurfactant-producingStreptomycesisolates from hydrocarbon-contaminated soil".International Journal of Pharma and Bio Sciences,vol. 4, No. 1, pp 524-535, Jan 2013.[Indexed in SCOPUS, Impact Factor 0.4]
  • R. Gabrani,R. Jain, A. Sharma, I.P. Sarethy, S. Dang and S. Gupta "Antiproliferative Effect ofSolanum nigrumon Human Leukemic Cell Lines"Indian Journal of Pharmaceutical Sciences vol. 74, pp. 451-453, Sep. 2012.[Indexed in SCOPUS, Impact factor:0.626]
  • R. Sreejith, J. Rana, N. Dudha, K. Kumar,R. Gabrani, S. K. Sharma, A. Gupta, S. Vrati, V. K. Chaudhary and S. Gupta,"Mapping of interactions among Chikungunya virus nonstructural proteins"Virus Research,vol. 169, pp. 231-6, Oct. 2012.[Indexed in SCOPUS, Impact factor:3]
  • S. Gupta, N. Dudha, M. B. Appaiahgari, K. Bharati, D. Gupta, Y. Gupta, K. Kumar,R. Gabrani, S. K. Sharma, A. Gupta, V. K. Chaudhary and S. Vrati,"Molecular cloning and characterization of Chikungunya virus genes from Indian isolate of 2006 outbreak"Journal of Pharmacy Research,vol. 5, pp. 3860-3863, Aug. 2012.[Indexed in DOAJ]
  • K. Kumar, J. Rana, R. Sreejith,R. Gabrani, S. K. Sharma, A. Gupta, V. K. Chaudhary and S. Gupta,"Intraviral protein interactions of Chandipura Virus"Archives of Virology,vol.157, pp. 1949-1957, Oct. 2012.[Indexed in SCOPUS, Impact factor:2.1]
  • S. Gupta, J.K. Sahni, J. Ali,R. Gabraniand S. Dang, "Development and Characterization of Green Tea Loaded Microemulsion for Vaginal Infections",Advanced Material letters,vol. 3, pp. 493-497, Dec. 2012.[Indexed in SCOPUS]
  • A. Sharma, S.Gupta, I.P. Sarethy, S. Dang, andR. Gabrani, "Green tea extract: possible mechanism and antibacterial activity on skin pathogens"Food Chemistry,vol. 135, pp. 672-675, Nov. 2012.[Indexed in SCOPUS, Impact factor: 3.655]
  • A. Agrawal,S. DangandR. Gabrani, "Recent Patents on Anti-Telomerase Cancer Therapy".Recent Patents on Anticancer Drug Discovery,vol. 7, pp. 102-17, Jan 2012.[Indexed in SCOPUS, Impact factor: 2.82]
  • K. Banerjee, U. Gupta, S.Gupta, G.Wadhwa,R. Gabrani, S. K. Sharma and C. K. Jain,"Molecular docking of glucosamine-6-phosphate synthase inRhizopus oryzae".Bioinformation,vol. 7, pp. 285-290, Nov. 2011.[Indexed in PUBMED, Impact factor:1.15]
  • U. Gupta, K. Banerjee,R. Gabrani, S. Gupta, S. K. Sharma and C. K. Jain, "Variability analyses of functional domains within glucosamine-6-phosphate synthase of mycoses-causing fungi"Bioinformation,vol. 6, pp. 196-199, May 2011.[Indexed in Pubmed, Impact factor:1.15]
  • S. Gupta,R. Gabrani,J. Ali and S. Dang, "Exploring Novel Approaches to Vaginal Drug Delivery".Recent Patents on Drug delivery and Formulations, vol. 5, pp. 82-94, May 2011.[Indexed in SCOPUS]
  • R. Jain, A. Sharma, S. Gupta, I.P. Sarethy andR. Gabrani, "Solanum nigrum: Current perspectives on therapeutic properties".Alternative Medicine Review,vol. 16, pp. 78-85, Mar 2011. [Indexed in SCOPUS, Impact factor: 3.52]
  • I.P. Sarethy, N. Gulati, A. Bansal, V. Gupta, K. Malhotra andR. Gabrani, "Genetic structure of an endangered Cycas revoluta using RAPD markers".Research Journal of Biotechnology,Vol. 6, pp. 50-55, Feb. 2011[Indexed in SCOPUS]
  • N. Shanker, N. Vikram, A. Tyagi,R. Gabrani, and I.P. Sarethy,"Study of Streptomyces diversity in arid and semi-arid soil of India".Journal of Pure & Applied Microbiology,vol. 4, pp. 687-699, Oct 2010.[Indexed in SCOPUS]
  • A. K. Patra, R.Mukhopadhyay, R. Mukhija,A. Krishnan, L. C. Garg, and A. K. Panda, "Optimization of inclusion body solubilization and renaturation of recombinant human growth hormone fromEscherichia coli",Protein Expression and Puriication,vol. 18, pp. 182-192, Mar 2000.[Indexed in SCOPUS, Impact factor: 1.621]
  • R. Mukhijaand L. C. Garg "N-terminus of mature heat-labile enterotoxin chain B is critical for its extracellular secretion inVibrio cholerae",FEBS Letters, vol. 463, pp. 336-340, Dec 1999.[Indexed in SCOPUS, Impact factor: 3.264]
  • L.C. Garg, R. Mukhija, P. Das, G. Tiwari, A.K. Panda, P. Rupa "High level expression and single step purification of the 3-subunit of human chorionic gonadotrophin in E. coli and its immunogenicity in rats" FASEB Journal, vol. 11(9):A1204, 1997.[Indexed in SCOPUS, Impact factor: 5.48]
  • R. Mukhija,P. Rupa, D. Pillai, and L. C. Garg, "High-level production and one-step purification of biologically active human growth hormone inEscherichia coli",Gene, vol. 165, pp. 303-306, Nov 1995.[Indexed in SCOPUS, Impact factor: 2.578]

SPONSORED R&D PROJECTS

  • Development of Natural Product Laboratory for Advance Research. DST-FIST; Rs. 66 Lakhs, Centre Representative: Reema Gabrani (2022-2027)
  • Analysis of host interactors of Chikungunya virus non structural Protein 1. CSIR; Rs. 10.68 Lakhs, Supervisor: Reema Gabrani; CSIR-SRF: R. Ghildiyal (2019-2022) 
  • Identification of cellular targets of chikungunya virus non structural proteins: Indian Council of Medical Research (ICMR), Govt. of India; Grant value: Rs. 34.1 Lakhs, PI: Sanjay Gupta; co-I:Reema Gabrani; (2016-2019).
  • Development and evaluation of green tea catechins based intravaginal nanoemulsion gel for the treatment of urinary tract infections: Department of Biotechnology (DBT), Govt. of India, Grant value: Rs.23.35 lakhs, PI: Shweta Dang; co-I: Javed Ali, co-I:Reema Gabrani; (2013-2016).
  • Viral-viral and viral-host protein interactions in Chandipura virus mediated encephalitis: Department of Science and Technology (DST), Govt. of India, Grant value:Rs. 35.6 Lakhs,PI: Sanjay Gupta; co-I:Amita Gupta; co-I:Reema Gabrani(2010-2013).
  • Mapping of the interactions among Chikungunya virus proteins (CHIKV viral-viral interactions): Department of Biotechnology (DBT), Govt. of India, Grant value: Rs.24.869 Lakhs, PI: Sanjay Gupta;co-I:Reema Gabrani;co-I:Prof. V.K. Chaudhary (2008-2012).

GENBANK SUBMISSIONS

  • G. Sharma, N.P. Singh, A. Tiwari, S. Gupta and R. Gabrani,Lactococcus lactis16S ribosomal RNA gene, partial sequence. Genbank Accession No.KP671842, 2015.
  • G. Sharma, N.P. Singh, A. Tiwari, S. Gupta and R. Gabrani, Pediococcus acidolacti16S ribosomal RNA gene, partial sequence. Genbank Accession No. KP671843, 2015.
  • G. Sharma, S. Gupta and R. Gabrani, Bacillus subtilisstrain GAS101 16S ribosomal RNA gene, partial sequence. Genbank Accession No. KJ564301, 2014. S. Gupta, N. Dudha, K. Kumar, R. Gabrani, S.K. Sharma, A. Gupta, and V. K. Chaudhary, Submitted following Genbank SUBMISSIONS:
  • Full-length cloned sequence of the non-structural protein 1 (nsP1) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272473, Jan. 31, 2011.
  • Full-length cloned sequence of the non-structural protein 2 (nsP2)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272474, Jan. 31, 2011.
  • Full-length cloned sequence of the non-structural protein 3 (nsP3)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272475, Jan. 31, 2011.
  • Full-length cloned sequence of the non-structural protein 4 (nsP4)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272476, Jan. 31, 2011.
  • Full-length cloned sequence of the capsid protein gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272477, Jan. 31, 2011.
  • Full-length cloned sequence of the Envelope protein 3 (E3) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272478, Jan. 31, 2011.
  • Full-length cloned sequence of the Envelope protein 2 (E2) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272479, Jan. 31, 2011.
  • Full-length cloned sequence of the Envelope protein 1 (E1) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272480, Jan. 31, 2011.
  • Full-length cloned sequence of the 6K gene of Chikungunya virus,isolate IND-06-Guj, of 2006 outbreak. Genbank Accession No. JF272481, Jan. 31, 2011.
  • I.P. Sarethy, N. Panjiar, and R. Gabrani, 16S rDNA sequence of Streptomyces isolate PN-18, capable of producing biosurfactant on complex carbon substrates. Accession no. GQ856644, Sep.29, 2009.
  • I.P. Sarethy, N. Shanker, N. Vikram, A. Tyagi, and R. Gabrani, 16S rDNA sequence of Streptomyces isolate B-14, capable of growing on complex carbon substrates. Accession no. GQ426322, Sep.1, 2009.

TECHNOLOGY TRANSFER

R. Mukhija, A. K. Panda, L. C. Garg, (2010) Successful Technology Transfer of vector for human growth hormone to Indian Immunologicals Ltd. (National Institute of Immunology).

Book

P. Gauba, R. Gabrani, G. Mathur (Eds), Recent Trends in Biosciences and Biotechnology, Vidya Kutir Publications, 2021; ISBN: 978-81-953535-8-3; DOI: https://doi.org/10.48002/BOOK.2021.RTBAB 

BOOK CHAPTER

  • V. Prakash, P. Bhatia, S. Dang, P. Gauba, R. Gabrani, “A Paradigm Shift as Therapeutics for COVID-19” Jen-Tsung Chen (Ed): Bioactive Compounds Against SARS-CoV-2, Chapter 4, 14 pages, Sep. 2023, CRC Press, eBook ISBN9781003323884, DOI: https://doi.org/10.1201/9781003323884

  • R. Gabrani, M. Ishaque, and K. Jain, “Phytochemical and Pharmacological Activities of Melissa officinalis (Lemon Balm)” T. Pullaiah (Ed.): Bioactives and Pharmacology of Lamiaceae, Chapter 25, pp. 331- 342.  Apple Academic Press, Aug 2023, ISBN: 978-1-77491-293-5; Series: AAP Focus on Medicinal Plants Series

  • R. Gabrani, U. Naithani and J. Jain, “Biomolecules and Pharmacology of Nepeta cataria L. (Family: Lamiaceae)” T. Pullaiah (Ed.): Bioactives and Pharmacology of Medicinal Plants (2-volume set)), Vol. 1, Chapter 29, pp. 369- 378.  Ed: T. Pullaiah, Apple Academic Press, June 2022, ISBN: 978-1-77491-101-3 Series: AAP Focus on Medicinal Plants Series
  • V. Prakash and R. Gabrani, “Silybum marianum (L.) Gaertn. (Milk Thistle)” T. Pullaiah (Ed.): Bioactives and Pharmacology of Medicinal Plants (2-volume set)), Vol. 2, Chapter 34, pp. 15-24, June 2022. Apple Academic Press, ISBN: 978-1-77491-103-7 Series: AAP Focus on Medicinal Plants Series
  • Verma, R. Simalty and R. Gabrani, "Antibiotic-Resistant Klebsiella pneumoniae and Targeted Therapy" Vinay Kumar et al. (Eds): Antimicrobial Resistance, Chapter 9, pp. 233-252, 2022. Springer Nature 978-981-16-3119-1, 495669_1_En
  • V. Prakash and R. Gabrani, “Recent Nanotechnology Based Advancements in Interventions for Glioblastoma Multiforme” P. Gauba, R. Gabrani, G. Mathur (Eds): Recent Trends in Biosciences and Biotechnology, Chapter 2, pp. 16-26, 2021. Vidya Kutir Publications, ISBN: 978-81-953535-8-3; DOI: https://doi.org/10.48002/BOOK.2021.RTBAB
  • U. Naithani and R. Gabrani, “The Androgen Receptor Pathway as A Therapeutic Target for Prostate Cancer” P. Gauba, R. Gabrani, G. Mathur (Eds): Recent Trends in Biosciences and Biotechnology, Chapter 4, pp. 43-65, 2021. Vidya Kutir Publications, ISBN: 978-81-953535-8-3; DOI: https://doi.org/10.48002/BOOK.2021.RTBAB
  • M. Gautam and R. Gabrani, “High Grade Brain Tumour & Drug Resistance” P. Gauba, R. Gabrani, G. Mathur (Eds): Recent Trends in Biosciences and Biotechnology, Chapter 11, pp. 156-167, 2021. Vidya Kutir Publications, ISBN: 978-81-953535-8-3; DOI: https://doi.org/10.48002/BOOK.2021.RTBAB
  • V. Prakash and R. Gabrani, “Role of Biomarkers in Developing Therapies for Glioblastoma Multiforme” Atta-ur-Rahman, M.I. Choudhary (Eds.): Frontiers in Anti-Cancer Drug Discovery, 2021, Vol. 12, Chapter 5, pp. 141-163, 2021. Bentham Science Publishers ISBN (Print): 978-981-14-8736-1 
  • K. Nigam, P.H.Ruba, P.Kapoor, R. Gabrani, S.Dang, Nano-carriers for Natural Therapeutics in Management of Neuropathic Pain. In: Talegaonkar S., Rai M. (eds) Nanoformulations in Human Health. pp. 361-376, 2020 Springer, Cham. https://doi.org/10.1007/978-3-030-41858-8_16(Springer Nature Switzerland AG 2020)                                                                  
  • A. Kaur, R. Bansal, S. Gupta, R. Gabrani, and S. Dang, “Nanoemulsions: Status in Antimicrobial Therapy” In “Smart healthcare system”, Eds. M. Rathi, A. Sinha: Taylor and Francis CRC press, ISBN: 978-0-367-03000-1 Chapter 6, 83-107, 2019
  • R. Ghildiyal, V. Prakash, V.K. Chaudhary, V.Gupta, R. Gabrani "Phytochemicals as Antiviral Agents: Recent Updates" In “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” Ed. M. K. Swamy, Vol 2 12 May 2020;279‐295. doi:10.1007/978-981-15-1761-7_12 Springer ISBN 978-981-15-1761-7 (eBook)
  • G. Maheshwari, B.P. Chauhan, S. Dang, and R. Gabrani, “Treatment of Lung Cancer in the New EraInFrontiers in Anti-Cancer Drug Discovery” Eds. Atta-ur-Rahman and M.I. Choudhary, Bentham Science Publishers, 2019, chapter 4, Vol. 11, pp 101-116. ISBN: 978-981-14-2212-6
  • R. Gabrani, R. Ghildiyal, N. Pratap, G. Sharma, S. Dang, “The applications of protein nanoparticles as drug delivery vehicle” In “Smart Healthcare Systems” Eds. M. Rathi, A. Sinha: Taylor and Francis (CRC Press). ISBN: 978-0-367-03000-1, chapter 13, 199-215 2019
  • M. Gautam, S. Srivastav, N. Tiwary, S. Dang, R. Gabrani."Phytotherapeutics: The Substitutes for Glioblastoma Multiforme" In"Natural Bioactive compounds: Production and Applications". Eds: M. S. Akhtar and M. K. Swamy, Springer Nature Singapore Pte Ltd., Singapore 2019, Vol. 2, chapter 9, pp. 201-214. 
  • M. Gautam, S. Singh, M. Aggarwal, MK. Sharma, S. Dang, R. Gabrani "Glioblastoma Multiforme; Drug Resistance & Combination Therapy" In "Frontiers in Anti-Cancer Drug Discovery" Eds. Atta-ur-Rahman and M.I. Choudhary, Bentham Science Publishers, 2019, chapter 5, Vol. 10, pp 111-130. ISBN:978-981-14-0191-6
  • S. Srivastava,G. Jain, S. Dang, S. Gupta and R. Gabrani, "Phytochemicals Targeting ER Stress to Inhibit Cancer Cell Proliferation" In "Anticancer Plants: Natural Products and Biotechnological Implements"Editors: M. S. Akhtar and M. K. Swamy; Springer, 2018, Vol. 2, chapter 12, pp. 273-287. ISBN:978-981-10-8063-0.
  • G.Gaur, U.L. Raj, S.Dang, S.Gupta,R.Gabrani"Plant-derived Drug Molecules as Antibacterial Agents" In "Functional Food and Human Health" Ed. V. Rani and U.C.S. Yadav; Springer, 2018
  • U. L. Raj, G. Sharma, S. Dang, S. Gupta, R. Gabrani "Impact of Dietary Supplements on Skin Aging" In "Textbook of Aging Skin" 2nd Ed. M.A. Farage, K.W. Miller, H.I. Maibach; Springer, ISBN:978-3-642-27814-3, 2017.
  • A. Agrawal, S. Dang and R. Gabrani "Recent Advances in Anti-Telomerase Cancer Therapy" In "Topics in Anti-Cancer Research" Volume 3, Ed Atta-ur-Rahman and K. Zaman; Bentham Science Publishers, 2014, chapter 16, pp. 581-631.
  • R. Gabrani, G. Sharma, S. Dang, S. Gupta "Role of ROS in bacterial resistance and biofilm formation and possible therapeutics" In "Free Radicals in Human Health & Diseases" Ed. V. Rani and U.C.S. Yadav; Springer, 2014, chapter 23, pp. 369-379.
  • S. Dang, S. Gupta, R. Bansal, J. Ali and R. Gabrani "Nano encapsulation of Green Tea Catechins – key to preserve its anti-oxidative potential" In "Free Radicals in Human Health & Diseases" Springer, 2014, chapter 25, pp. 397-415.
  • R. Gabrani. "Cancer biology and RNAi" in Modern Biotechnology and its applications Part 2. Kambaska Behera, Ed. New India Publication Agency, N. Delhi, India. 2013, pp. 513-542.

PH.D. GUIDANCE

  • Ritu Ghildiyal (2023): Elucidation of host-chikungunya virus non-structural protein interactions and in silico analysis for co-infection (as PI)

  • Garima Agarwal (2022): Identification and Characterization of Peptide Binders for Chikungunya Virus Envelope 2 Protein (as PI)

  • Atinderpal Kaur (2020): Development of Drug Loaded Nanoemulsion Based Formulations for Urinary Tract Infection. (as Co-PI)
  • Garima Sharma (2017): Purification, characterization and antibacterial studies of bacteriocins from dairy farm isolates. (as PI)
  • Sonal Gupta (2015): Development of Nano-Carrier Based Antibacterial Formulation of Green Tea and Synergistic Phytochemicals. (as Co-PI)
  • Namrata Dudha (2015) Topic: Mapping interactions of Chikungunya Virus structural Proteins. (as Co-PI)
  • Kapila Mehta (2013) Topic: Intraviral Protein Interactions of Chandipura Virus. (as Co-PI)