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Thrust Areas / Major Research Areas / Major Research Groups

1. Area / Group Name:Centre for Emerging Diseases
Center coordinator: Dr Sanjay Gupta
2. A brief write-up covering importance of area, its present status, activities completed at JIIT and activities going on and those proposed to be taken up in near future.

Newly emerged, re-emerged infectious and life style diseases constitute a global threat that puts every nation and every person at risk. ‘Centre for Emerging Diseases’ address questions of molecular pathogenesis of emerging viral and bacterial pathogens (host pathogen interactions, essential metabolic pathways of pathogens), structural biology, life style diseases such as cancer, cardiovascular diseases and the design of novel diagnostics and therapeutics. The research activities at the ‘Centre for Emerging Diseases’ is supported by extramural research funding from various agencies of Govt. of India including Department of Biotechnology (DBT), Department of Science & Technology (DST), Indian Council of Medical Research (ICMR) and All India Council for Technical Education (AICTE).

Newly emerged and re-emerged diseases in the recent past caused by SARS, Chikungunya (CHIKV) and other viruses have amply highlighted the vulnerability of developing and developed nations. Research is being carried out on emerging/re-emerging pathogens specifically CHPV, endemic to India with 70% mortality among children and CHIKV with its annual large scale outbreaks in the country since 2006 when it infected ~1.6 million individuals. The on-going research objectives are to understand the molecular and cell biology of pathogen-host-vector interactions in these emerging viral diseases; study the pathogen specific remodeling processes of the host/vector cell; identify interactions which could be target for therapeutics and identify peptide based inhibitors. The emerging viruses research is funded by several research grants worth ~ 2 crore from Govt. of India funding agencies that include DBT, DST, ICMR and AICTE.

In view of the rapid pace with which multidrug resistant strains of almost all group of pathogens are emerging, the need for new antibacterial compounds cannot be overemphasized. Research efforts have been initiated for early-stage rational drug discovery for a novel antimicrobial agent(s). X-ray crystal structure of a potential drug target from human pathogens responsible for infecting respiratory and/or gastrointestinal tract is being elucidated. The availability of the 3D – structural information of a drug target from many pathogenic organisms will enable the possibility of rational structure-based design and development of both a broad-spectrum and conversely, a pathogen-specific drug molecule.

Another major area of focus is to understand the mechanism and study the role of natural compounds in combating them cancer, metabolic, neurological disorders and cardiovascular diseases. India is the vast reservoir of living traditions of ethno medicine of which many are known to have role in cancer and cardiac protection. Besides the extensive use of these Ayurveda medicines, herbal remedies have not undergone rigorous scientific assessment at their molecular, biochemical and toxicological levels. Continuing research is necessary to identify the right biomolecules in appropriate doses which are non toxic, least interactive with other drugs and disease preventive in nature. Gene regulatory elements like MicroRNAs (miRNAs) and transcription factors are researched extensively to understand the gene regulation and may lead to novel therapeutics.

The bioinformatics group construct networks of complex systems, does data mining & pattern recognition, implement machine leaning systems, and develop sophisticated tools and pipelines to solve problems relevant to disease biology.nt: Sreejith Rajasekharan) Indian Council of Medical Research (ICMR),Govt. of India, Duration: 2014-2015, Grant Value: 3.0 lakh, Faculty mentor:Dr. Sanjay Gupta.

For complete details- Please see

5. Details of publications, patents and Process / Equipment / Software Developed.
Publications: (International): 132

2015

  • Rajasekharan, S., Kumar,K., Rana,J., Gupta,A., Chaudhary V.K., Gupta,S., “Host interactions of Chandipura virus matrix protein” Acta Tropica 149 pp.27–31,2015 [Indexed in Scopus]
  • Jain,C.K., Arora,S., Khanna,A., Gupta,M., Wadhwa,G., Sharma, S.K., The Ubiquitin-Proteasome Pathway an Emerging Anticancer Strategy for Therapeutics: A Patent Analysis, Recent patents on anti-cancer drug discovery 10 (2), 201-213. [Impact factor 2.86; Indexed in SCOPUS]
  • Jain, A., Atale, N., Kohli, S., Bhattacharya, S., Sharma, M. and Rani, V. “An assessment of norepinephrine mediated hypertrophy to apoptosis transition in cardiac cells: A signal for cell death”. Chem Biol Interact. Vol. 225, pp. 54-62, 2015. [Indexed in Scopus, Impact factor: 2.982]
  • Bajpai, N, Chatterjee, A, Dang, S, Sharma, S. K., “Metrics for leveraging more in Clinical Data Management: proof of concept in the context of vaccine trials in an Indian pharmaceutical company”.Asian Journal of Pharmaceutical and Clinical Research, Vol 8 (3), 350-357, 2015
  • Bajpai, N, Chatterjee, A, Dang, S, Sharma, S. K., “Insights in paper Case Report Form Design from Vaccine Trials in an Indian Pharmaceutical Company: Clinical Data Management prospective”. International Journal of PharmTech Research, Vol 8 (1), 146-153, 2015
  • Bajpai, N; Dang, S; Sharma, S. K., “Standardize Operating procedure for Clinical Data Management (CDM), exploring the possibility under Indian Regulations”. International Journal of Pharmaceutical and Clinical Research, Vol 7 (3), 2015
  • Tanuja Yadav, Mishra S, Das S, Aggarwal S, Rani V.”Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin”.Environ Toxicol Pharmacol., Vol. 9(1):384-391, 2015.
  • Raghav R. and Srivastava S. “Core-shell Gold-Silver nanoparticles based impedimetric immunosensor for cancer antigen CA125″ Sensors and Actuators :B Chemical, DOI: 10.1016/j.snb.2015.05.108 2015
  • P. Nag, R. Rajput, S. Dhaliwal, S. Kumar, D. Prajapat, M. Singh, Formulation and Characterization Of Propranolol Nanoparticles For Transmucosal Nasal Drug Delivery, Macromolecular symposia, Volume 347,Issue 1,pages 32–38,January 2015. [Indexed in Scopus, Impact factor: 0.913].
  • Sharma, D., Sharma, R.K., Sharma, N., Gabrani, R.,Sharma, S.K., Ali,J. and Dang, S. “Nose-to-brain delivery of PLGA-diazepam nanoparticles”. AAPS Pharm Sci Tech. DOI: 10.1208/s12249-015-0294-0, 2015. [Indexed in Scopus, Impact factor: 1.776]
  • Kalsi, A., Singh, S., Taneja, S.K. and Mani, S. “Current treatments for type 2 diabetes, their side effects and possible complementary treatments”. Int J Pharm Pharm Sci. Vol. 7(3), pp. 315-318, 2015. [Indexed in Scopus, Impact factor: 0.91]
  • Singh, N.P., Tiwari, A., Bansal, A., Thakur, S., Sharma, G. and Gabrani, R. “Genome level analysis of bacteriocins of lactic acid bacteria”. Comput Biol Chem. Vol. 56, pp. 1-6, 2015. [Indexed in Scopus, Impact factor: 1.595]
  • Dudha, N., Rana, J., Rajasekharan, S., Gabrani, R., Gupta, A., Chaudhary, V.K. and Gupta, S. “Host-pathogen interactome analysis of Chikugunya virus envelope proteins E1 and E2”. Virus Genes. Vol. 50(2), pp. 200-209, 2015. [Indexed in Scopus, Impact factor: 1.9]
  • Jain, C.K., Gupta, M., Prasad, Y., Wadhwa, G. and Sharma, S.K. “Homology modelling and molecular dynamics simulations of a protein serine/threonine phosphatase stp1 in Staphylococcus aureus N315: a potential drug target”. Mol Simulat. Vol. 41(7), pp. 592-599, 2015. [Indexed in Scopus, Impact factor: 1.11]

2014

  • Chauhan, R.,Wadhwa, G.,Sharma, S.K. andJain, C.K. “Current developments in therapeutic and diagnostic strategies for Q fever: Glimpses of patent analysis”. Recent patents on anti-infective drug discovery. Vol. 9(2), pp. 104-11, 2014. [Indexed in Scopus]
  • Chauhan, R.,Wadhwa, G.,Sharma, S.K. and Jain, C.K. “Patent prospects toward therapeutics and diagnostics of anthrax”. Recent Pat Antiinfect Drug Discov. Vol. 9 (1), pp. 52-61, 2014. [Indexed in Scopus]
  • Bhaskar, A., Raturi, K., Dang, S. and Gabrani, R. “Current perspectives on the therapeutic aspects of chronic myelogenous leukemia”. Expert Opin Therap Pat. Vol. 24, pp. 1117-1127, 2014. [Indexed in Scopus, Impact factor: 3.4]
  • Raghav, R. and Srivastava., S. “Direct ELISA-based reagentless amperometric immunosensor for cancer antigen 125”. Nanotrends. Vol 16(2), pp. 1-6, 2014.
  • Dudha, N., Rana, J., Gabrani, R., Gupta, A., Chaudhary, V.K. and Gupta, S. “Small scale expression, solubilisation and characterization of Chikungunya virus structural proteins”. Asian J Pharm Clin Res. Vol. 7(5), pp.268-271, 2014. [Indexed in Scopus].
  • Singh, A.,Budhraj, A.,Shrivastava, A.,Satyavana, A.,Gupta, A.,Gupta, M.,Wadhwa, G.,Sharma, S.K. andJain, C.K. “Current status of anti-tuberculosis therapy: A patent analysis”. Recent Pat Antiinfect Drug Discov Vol. 9(1), pp. 25-40, 2014. [Indexed in Scopus]
  • Sarethy, I.P., Kashyap, A., Bahal, U., Sejwal, N. and Gabrani, R. “Study of liquid culture system for micropropagation of the medicinal plant Solanum nigrum L. and its effect on antioxidant property”. Acta Physiol Plant, DOI 10.1007/s11738-014-1655-0, 2014. [Indexed in Scopus Impact factor: 1.732]
  • Rana, J., Rajasekharan, S., Gulati, S., Dudha, N., Gupta, A., Chaudhary, V.K. and Gupta, S. “Network mapping among the functional domains of Chikungunya virus nonstructural proteins.” Proteins. Vol. 82(10), pp. 2403-2411, 2014. [Indexed in Scopus, Impact factor: 3.3]
  • Sharma, D., Maheshwari, D., Philip,G., Rana, R., Bhatia, S., Singh, M., Gabrani, R., Sharma, S.K., Ali, J., Sharma, S.K. and Dang, S. “Formulation and optimization of polymeric nanoparticles for intranasal delivery of lorazepam using box-behnken design: in vitro and in vivo evaluation”. Biomed Res Int. Vol. 2014, Article ID 156010, pp. 14, 2014. [Indexed in Scopus, Impact factor: 2.7]
  • Atale, N., Gupta, S., Yadav, U.C.S. and Rani, V. “Cell-death assessment by fluorescent and nonfluorescent cytosolic and nuclear staining techniques”. J Microsc. Vol. 255, pp.7-19, 2014. [Indexed in Scopus, Impact factor: 2.15]
  • Gupta, S., Bansal, R., Ali, J., Gabrani, R. and Dang, S. “Development and characterization of Polyphenon 60 and caffeine microemulsions for enhanced antibacterial activity”. Biomed Res Int. Vol. 2014, Article ID 932017, pp. 7, 2014. [Indexed in Scopus, Impact factor: 2.7]
  • Jain, C.K., Gupta, M., Prasad, Y., Wadhwa, G. and Sharma, S.K. “Homology modeling and protein engineering of alkane monooxygenase in Burkholderia thailandensis MSMB121: in silico insights”, Journal of Molecular Modeling, Vol. 20(7), pp. 2340-2351, 2014. [Indexed in Scopus, Impact factor: 1.9]
  • Sharma, G., Raturi, K., Dang, S.,Gupta, S. and Gabrani, R., “Combinatorial antimicrobial effect of curcumin with selected phytochemicals on Staphylococcus epidermidis”. Journal of Asian Natural Products Research. Vol. 16(5), pp. 535-541, 2014. [Indexed in Scopus, Impact factor: 0.97]
  • Sharma, D., Gabrani, R.,Sharma, S.K., Ali, J. and Dang, S., “Development of Midazolam Loaded Poly (D, L-lactide-co-glycolic acid) Nanoparticles for Treatment of StatusEpilepticus”.Adv. Sci. Lett. Vol. 20(7-9),pp. 1526-1530, 2014. [Indexed in Scopus, Impact Factor: 1.2]
  • Gupta, S., Bansal, R., Maheshwari, D., Ali, J., Gabrani R. andDang,S. “Development of a Nanoemulsion System for Polyphenon 60 and Cranberry”. Adv. Sci. Lett. Vol. 20 (7-9), pp.1683-1686, 2014. [Indexed in Scopus, Impact Factor: 1.2]
  • Jain, C.K., Sethi, R., Sharma, V., Mathur, A. and Sharma, S.K. “Enhanced interaction of shuffled Mutacin IV, an antimicrobial peptide of bacterial origin, with surface protein ISDB of Staphylococcus aureus”, International Journal of Peptide Research and Therapeutics. Vol. 20(1), pp. 71-76, 2014. [Indexed in Scopus, Impact factor: 0.825]
  • Rawal, S., Singh, P., Gupta, A. and Mohanty, S. “Dietary intake of curcuma longa and Emblica officinalis increases life span in Drosophila melanogaster’, Biomed Res Int. Vol. 2014, Article ID 910290, 2014. [Indexed in Scopus, Impact factor: 2.706]
  • Rajasekharan, S., Rana, J., Gulati, S., Gupta, V. and Gupta, S. “Neuroinvasion by Chandipura virus.” Acta Trop, Vol. 135, pp. 122-126, 2014. [Indexed in Scopus, Impact factor: 2.8 ]
  • Jain, C.K., Gupta, A., Dogra, N., Kumar, V.S., Wadhwa, G. and Sharma, S.K. “MicroRNA therapeutics: The emerging anticancer strategies”. Recent Pat Anticancer Drug Discov. Vol. 9(3), pp. 286-296, 2014. [Indexed in Scopus, Impact Factor: 2.7].
  • Atale, N., Gupta, K. and Rani, V. (2014). Protective effect of Syzygium cumini against pesticide-induced cardiotoxicity. Environ Sci Pollut Res. Vol. 21(13), pp. 7956-7972, 2014. [Indexed in Scopus, Impact Factor: 2.618]
  • Bajpai, N., Dang, S. and Sharma, S.K. “Clinical data management operational model for the conduct of Myfive™ vaccine study”. International Research Journal of Humanities, Engineering & Pharmaceutical Sciences (IJHEPS™). Vol. 1(7), pp. 2249-2569, 2014.
  • Chadah, R., Shah, R. and Mani, S. “Analysis of reported SCO2 gene mutations affecting cytochrome c oxidase activity in various diseases”. Bioinformation, Vol. 10(6), pp. 329-333, 2014.

2013

  • Kumar, K., Rajasekharan, S., Gulati, S., Rana, J., Gabrani, R.,Jain, C.K., Gupta, A., Chaudhary V.K. and Gupta, S. “Elucidating the interacting domains of Chandipura virus Nucleocapsid protein”. Advances in Virology. Vol. (2013) Article ID 594319, 2013. [Indexed in Scopus]
  • Kaushik, P., Jain, C.K.,Gabrani, R. and Singh, T.R. “Study on variability assessment and evolutionary relationships of glutamate racemase in Pseudomonas species”. Interdisciplinary Sciences: Computational Life Sciences. Vol. 5(4), pp. 247-257, 2013. [Indexed in Scopus, Impact factor: 0.672].
  • Kohli, S., Chhabra, A., Jaiswal, A., Rustagi, Y., Sharma, M. and Rani, V. “Curcumin suppresses gelatinase B mediated norepinephrine induced stress in H9c2 cardiomyocytes”. PLoS One. Vol. 8, pp. e76519-76531, 2013. [Indexed in Scopus, Impact factor: 3.534]
  • Aminu, N., Baboota, S., Pramod, K., Singh, M., Dang, S., Ansari, S.H., Sahni, J.K. and Ali, J. “Development and evaluation of triclosan loaded poly-ε-caprolactone nanoparticulate system for the treatment of periodontal infections”. Journal of Nanoparticle Research. Vol. 15(11), pp. 1-15, 2013. [Indexed in Scopus, Impact factor: 2.278].
  • Atale, N. and Rani, V. “GC-MS analysis of bioactive components in the ethanolic and methanolic extract of Syzygium cumini”. International Journal of Pharma and Bio Sciences. Vol. 4(4), pp. 296-304, 2013. [Indexed in Scopus, Impact factor: 0.67]
  • Jain, C.K., Gupta, A., Tewari, A., Sharma, V., Kumar, V.S., Mathur, A. and Sharma, S.K. “Molecular docking studies of bacoside fromBacopa monnieriwith LRRK2 receptor”.Biologia,Vol. 68(6), pp. 1068-1071, 2013 [Indexed in Scopus, Impact factor: 0.5]
  • Sharma, S. and Srivastava, S. “Gold microwires based amperometric biosensor exploiting microbial architecture”. Biosensors and Bioelectronics. Vol. 50, pp. 174-179, 2013. [Indexed in Scopus, Impact factor: 5.437]
  • Rajasekharan, S., Rana, J., Gulati, S., Sharma, S. K., Gupta, V. and Gupta, S. “Predicting the host protein interactors of Chandipura virus using a structural similarity–based approach”. FEMS Pathogens and Disease. Vol. 69(1), pp. 29-35, 2013. [Indexed in Scopus, Impact factor: 2.44]
  • Gupta, S., Jain, A., Chakraborty, M., Sahni, J. K., Ali, J. and Dang, S. “Oral delivery of therapeutic proteins and peptides: a review on recent developments”. Drug Delivery. Vol. 20(6), pp. 237-246, 2013. [Indexed in Scopus, Impact factor: 1.930]
  • Jain, C.K., Dasgupta, A., Taneja, N., Chaubey, S., Gabrani, R.,Sharma, S.K. and Gupta, S. “Putative drug targets in Rhizopus oryzae: in-silico insight”. International Journal of Bioinformatics Research and Applications. Vol. 9(6), pp. 595-603, 2013. [Indexed in Scopus]
  • Rajasekharan, S., Gulati S. and Gupta S. “Interfacial interactions involved in biological assembly of Chandipura virus nucleocapsid protein”. Virus Genes. Vol. 46(3), pp. 535-537, 2013. [Indexed in Scopus, Impact factor: 1.79]
  • Rana, J., Rajasekharan, S., Gulati S., Bharti I., Jain S. and Gupta S. “Deciphering the host-pathogen interface in Chikungunya virus-mediated sickness.” Archives of Virology. vol. 158, no. 6, pp. 1159-1172, 2013. [Indexed in Scopus, Impact factor: 2.03]
  • Gupta, A., Verma, A., Mishra, A. K., Wadhwa, G., Sharma, S.K. and Jain, C.K. “The Wnt pathway: Emerging anticancer strategies”. Recent Pat Endocr Metab Immune Drug Discov. Vol. 7, pp.138-147, 2013. [Indexed in Scopus]
  • Gupta, M., Wadhwa, G., Sharma,S.K. and Jain, C.K. “Homology evolute and validation of SAS2271 transcriptional regulator of AraC family in Staphylococcus aureus”, Asian Pac J Trop Dis; 3(1): 1-4, 2013. [Indexed in Scopus, Impact factor: 0.37]
  • Jain, A., Manghani, C., Kohli, S, Nigam, D. and Vibha, R. “Tea and human health: The dark shadows”. Toxicol Lett. Vol. 220(1), pp. 82-87, 2013. [Indexed in Scopus, Impact factor: 3.706 ]
  • Arora, S., Rana, R., Chhabra, A., Jaiswal, A. and Rani, V. “miRNA-transcription factor interactions: a combinatorial regulation of gene expression”. Mol Genet Genomics. Vol. 288(3-4), pp. 77-87, 2013. [Indexed in Scopus, Impact factor: 2.831]
  • Atale, N., Chakraborty, M., Mohanty, S., Bhattacharya, S., Nigam, D., Sharma, M. and Rani, V. “Cardioprotective Role of Syzygium cumini Against Glucose-Induced Oxidative Stress in H9C2 Cardiac Myocytes”. Cardiovasc Toxicol. Vol. 13(3), pp. 278-289, 2013. [Indexed in Scopus, Impact factor: 2.060]
  • Roy, N., Gaur, A., Jain, A., Bhattacharya, S. and Rani, V. “Green synthesis of silver nanoparticles: An approach to overcome toxicity”. Environmental Toxicology and Pharmacology. Vol. 36(3), pp. 807-812, 2013. [Indexed in Scopus, Impact factor: 2.093]
  • Bajpai, N., Chatterjee, A., Dang, S. and Sharma, S.K. “A perspective of clinical data management in the context of the application of Indian Good Clinical Practices” International Journal of Technical Research and Applications. Vol. 1(4), pp. 35-38, 2013.
  • Shrivastav, A. and Srivastava, S. “Human Sweet Taste Receptor: Complete Structure Prediction and Evaluation”. Int. J of Chemical and Analytical sciences. Vol. 4, pp. 24-32, 2013. [Impact factor: 0.47]
  • Tewari, A.K., Rashi, Wadhwa, G., Sharma, S. K. and Jain, C.K. “BIRS – Bioterrorism Information Retrieval System”. Bioinformation Vol. 9(2), pp.112-115, 2013. [Impact factor:1.15]
  • Rustagi, Y. and Rani, V. “Screening of MicroRNA as potential CardiomiRs in Rattus noveregicus heart related dataset”. Bioinformation. Vol. 11(9), pp. 919-922, 2013.
  • Bajpai, N., Sharma, M., Chatterjee, A., Dang, S. and Sharma, S.K. “Standardization of procedural implementation in Clinical Data Management, with reference to the trials: DTwP-HepB-Hib vaccine (MyfiveTM) vs. Pneumococcal vaccine (NUCOVAC®)”. Indian Journal of Scientific Research (IJSR). Vol. 4(2), pp. 179-191, 2013.
  • Bajpai, N., Chatterjee, A., Dang, S. and Sharma, S.K. “Clinical data management: lessons drawn from vaccine clinical trials of an Indian pharmaceutical company”. The Pharma Review. Vol. 11(65), 2013.
  • Bajpai, N., Mohanty, L., Chatterjee, A., Dang, S. and Sharma, S.K. “Schematic depiction of CDM procedures: Based on the experiences drawn from the vaccine trials conducted in an Indian pharmaceutical company”. International Journal of Pharmaceutical Sciences. Vol. 2(5-6), pp. 93-96, 2013.
  • Nigam, D. and Rani, V. “Therapeutic Efficacy of Tumeric on 6-OHDA-Induced-neurodegeneration in albino rats”. International Journal of Medicine and Pharmaceutical Science (IJMPS). Vol. 3(1), pp. 27-38, 2013.
  • Gulati, N. and Mohanty, S. “Sex comb variation in four species of Drosophila species from Northern India”. International Journal of Biotechnology and Bioengineering Research. Vol. 4(4), pp.329-334, 2013.
  • Prachi, Balwani, I., Singh, P., Mayank., Gulati, N. and Mohanty, S. “Development of molecular markers for phylo- and population genomics of Indian Drosophila”. International Journal of Biotechnology and Bioengineering Research. Vol. 4(6), pp. 565-572, 2013
  • Bhatia, S., Rachana, Bansal, P. and Mani, S. “Mitochondrial diabetes: Different diagnostic features and its possible management”. J Int Med Sci Acad, 2013.
  • Chadha, R., Shah, R., Bansal, P. and Mani, S. “Cytochrome c oxidase deficiency and leigh syndrome: A possible therapeutic target”. J Med Sci Research.Vol. 4(1), 2013.

2012

  • Rajasekharan, S., Rana, J., Dudha, N., Kumar, K., Gabrani, R.,Sharma, S.K., Gupta, A., Vrati, S., Chaudhary, V.K. and Gupta, S. “Mapping of interactions among Chikungunya virus evolutegral proteins”. Virus Res. Vol. 169(1), pp. 231-236, 2012. [Indexed in Scopus, Impact factor: 3.0].
  • Kumar, K., Rana, J., Rajasekharan, S., Gabrani, R.,Sharma, S.K., Gupta, A., Chaudhary, V.K. and Gupta, S. “Intraviral protein interactions of Chandipura virus”. Arch Virol. Vol. 157, pp. 1949-1957, 2012. [Indexed in Scopus, Impact factor: 2.1].
  • Rawal, K., Dorji, S., Kumar, A., Ganguly, A. and Grewal, A.S. “Identification and characterization of MGEs and their insertion sites in the gorilla genome”. Mob Genet Elements, Vol. 3(4), pp. e25675- e25696, 2012. [Indexed in Scopus]
  • Iqbal, M.A., Shadab M., Sahni, J.K., Baboota, S., Dang, S. and Ali, J. “Nanostructured lipid carriers system: Recent advances in drug delivery”. J Drug Targeting. Vol. 20(10), pp. 813-830, 2012. [Indexed in Scopus, Impact factor: 3.08].
  • Chittoria, A., Mohanty, S., Jaiswal, Y. and Das A. “Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India”. PloS One. Vol. 7, pp. e45219, 2012. [Indexed in Scopus, Impact factor: 3.534]
  • Agrawal, A., Dang, S. and Gabrani, R. “Recent patents on anti-telomerase cancer therapy”. Rec Pat Anticancer Drug Discov. Vol. 7(1), pp. 102-117, 2012. [Indexed in Scopus, Impact factor: 2.82]
  • Dey, B., Thukral, S., Krishnan, S., Chakrobarty, M., Gupta, S., Manghani, C. and Rani, V. “DNA-protein interactions: methods for detection and analysis”. Mol Cell Biochem. Vol. 365(1-2), pp. 279-299, 2012. [Indexed in Scopus, Impact facto: 2.388]
  • Sharma, A., Gupta, S., Sarethy, I.P.,Dang, S. and Gabrani, R. “Green tea extract: possible mechanism and antibacterial activity on skin pathogens” Food Chem. Vol. 135(2), pp. 672-675, 2012. [Indexed in Scopus, Impact factor: 3.259]
  • Sharma, S., Gupta, N. and Srivastava, S. “Modulating electron transfer properties of gold nanoparticles for efficient biosensing”. Biosensors Bioelectron. Vol. 37, pp. 30-37, 2012. [Indexed in Scopus, Impact factor: 5.602]
  • Gabrani, R., Jain, R., Sharma, S., Sarethy, I.P.,Dang, S. and Gupta, S., “Antiproliferative effect of Solanum nigrum on human leukemic cell lines”. Indian J Pharma Sci. Vol. 74(5), pp. 451-453, 2012. [Indexed in Scopus, Impact factor: 0.3]
  • Chhabra, A., Jaiswal, A., Malhotra, U., Kohli, S. and Rani, V. “Cell in situ Zymography: An in vitro cytotechnology for localization of enzyme activity in cell culture”. In Vitro Cell Dev Biol Anim. Vol. 48(8), pp. 463-468, 2012. [Indexed in Scopus, Impact factor: 1.0]
  • Vats, T. and Priyadarshini. “Effect of calcium phosphate renal calculi extract on nucleation mineral phase”. J proteins proteomics. Vol. 3, pp. 47-48, 2012. [Impact factor: 0.15]
  • Jain, C.K., Gupta, V., Gupta, A., Gupta, S., Wadhwa, G., Sharma, S.K. and Sarethy, I.P. “Streptomyces inforSys: A web-enabled information repository”. Bioinformation. Vol. 8(25), pp. 1283-1285, 2012. [Impact factor: 0.5]
  • Bhaskar, B, Malik, A., Rawal, K. “Detecting motifs and patterns at mobile genetic element insertion site”. Bioinformation. Vol. 8(16), pp. 777-786, 2012. [Impact factor 1.1]
  • Nassa, M., Anand, P., Jain, A., Chhabra, A., Jaiswal, A., Malhotra, U. and Rani, V. “Analysis of human collagen sequences”. Bioinformation. Vol. 8, pp. 26-33, 2012. [Impact factor 1.1]
  • Rawal, K., Priya, A., Malik, A., Bahl, R. and Ramaswamy, R. “Distribution of MGEs and their insertion sites in the Macaca mulatta genome”. Mob Genet Elements. Vol. 2(3), pp. 133-141, 2012.
  • Bansal, P. and Mani, S. “Immunology of Diabetes Mellitus”. J Med Sci Res. Vol. 3, pp. 1-2, 2012.
  • Jaiswal, H.K., Rawal, K., Jaganadham, J. and Agrawal, S. “Evaluation of inhibition activity of Tetrahydrolipstatin analogues on Diacylglycerol lipase alpha usingin –silicotechniques”. J Pharm Res. Vol. 5(6), pp. 3473-3477, 2012.
  • Rawal, K. “Viral load reduction after homeopathy treatment in an obese individual with chronic hepatitis B infection”. WYNO J Med Sci. Vol. 1(1), pp. 1-6, 2012.
  • Agrawal, S., Rawal, K., Sahu, A., Mahajan, S., Garg, P. and Bahl, R.“To find gene distributions in PubMed abstracts using Perl software”. J Pharm Res. Vol. 5(12), pp. 5453-5456, 2012.
  • Bajpai, N., Chatterjee, A., Dang, S. and Sharma, S.K. “Clinical data management patrons: positions & skill requirements in the industry”. Clin Res plus. Vol. 3(1), pp. 18-21, 2012.
  • Gulati, S., Sharma, A., Rajasekharan, S., Sharma, S.K.,Jain C.K. and Gupta, S., “Polyethylene glycol 4000 (PE4) as potential antiviral agent against Chandipura Virus”. J Pharm Res. Vol. 5(3), pp. 1605-1607, 2012.
  • Dudha, N., Appaiahgari, M.B., Bharati K., Gupta, D., Gupta, Y., Kumar, K., Gabrani, R.,Sharma, S.K., Gupta, A., Chaudhary, V.K., Vrati, S. and Gupta, S. “Molecular cloning and characterization of Chikungunya virus genes from Indian isolate of 2006 outbreak”. J Pharm Res. Vol. 5(7), pp. 3860-3863, 2012.
  • Malhotra, U., Jaiswal, A., Chhabra, A., Atale, N. and Rani, V. “Computational structural and functional characterization of protein family: Key for the hidden mystery”. J Pharm Res. Vol. 5(7), pp. 3643-3649, 2012.
  • Sharma, S., Goswami, N., Gupta, N. and Srivastava, S. “Amino coated gold nanorods based amperometric glucose detection”. Inter J Adv Technol. Vol. 3(3), pp.195-202, 2012.
  • Sharma, S. and Srivastava, S. “Synthesis of branched gold nanostructures with improved biocompatibility”. Nanotrends. Vol. 13(1), pp.40-47, 2012.
  • Gulati, S., Sharma, A., Rajasekharan, S., Sharma, S.K.,Jain C.K. and Gupta, S. “Polyethylene glycol 4000 (PE4) as potential antiviral agent against Chandipura Virus”. J Pharm Res. Vol. 5(3), pp. 1605-1607, 2012.
  • Nigam, D, Rani, V. and Singh, K. “Protective role of turmeric in manganese-induced oxidative alterations in rat brain”. J Pure Applied Sci Technol. Vol. 2(2), pp. 5-11, 2012.
  • Gupta, S., Sahni, J.K., Ali, J., Gabrani, R. and Dang, S. “Development and characterization of green tea loaded microemulsion for vaginal infections”. Adv Materials Lett. Vol. 3(6), pp. 493-497, 2012. [Indexed in Scopus].

2011

  • Chakraborty, M., Jain, S. and Rani, V. “Nanotechnology: emerging tool for diagnostics and therapeutics.” Appl Biochem Biotechnol. Vo.l 165(5-6), pp. 1178-1187, 2011. [Indexed in Scopus, Impact factor: 1.879]
  • Guleria, A., Kiranmayi, M., Rajasekharan, S., Kumar, K., Sharma, S.K. andGupta, S. “Reviewing host proteins of Rhabdoviridae: Possible leads for lesser studied viruses”. J Biosci. Vol. 36(5), pp.1-9, 2011. [Indexed in Scopus, Impact factor:1.9]
  • Rawal, K. and Ramaswamy, R. “Genome wide analysis of mobile genetic elements insertion sites”. Nucl. Acids Res. Vol. 39(16), pp. 6864-6878, 2011. [Indexed in Scopus, Impact factor: 8.8]
  • Kumar, K., Rana, J., Guleria, A., Gupta, A., Chaudhary, V.K. and Gupta, S. “Expression and characterization of Chandipura virus proteins”. Res Biotechnol. Vol. 2(6), pp. 27-36, 2011. [Indexed in Scopus]
  • Ali, J., Gupta, S., Dang, S, Baboota, S., Shadab, Md., Ali, A., Iqbal, B. and Sahni, J.K. “Recent advances and patents in solid dispersion technology and some related issues”. Rec Pat Drug delivery Formulations. Vol. 5(3), pp. 244-264, 2011. [Indexed in Scopus]
  • Haque, S., Shadab, M., Fazil, M., Sahni, JK, Baboota, S., Dang, S. and Ali J. “Role of chitosan biomaterials in drug delivery systems: A patent perspective”. Rec Pat Materials Sci. Vol. 4(3), pp. 209-223, 2011. [Indexed in Scopus]
  • Gupta, S., Gabrani, R., Ali, J. and Dang, S. “Exploring Novel Approaches to Vaginal Drug Delivery”. Rec Pat Drug delivery Formulations. Vol. 5, pp. 82-94, 2011. [Indexed in Scopus]
  • Shruti, K., Shrey, K. and Rani, V. “Micro RNAs: Tiny sequences with enormous potential”. Biochem Biophys Res Commun. Vol. 407(3), pp. 445-449, 2011. [Indexed in Scopus, Impact factor: 2.595 ]
  • Jain, R., Sharma, A., Gupta, S.,Sarethy, I.P. and Gabrani, R. “Solanum nigrum: Current perspectives on therapeutic properties”. Alter Med Rev. Vol. 16, pp. 78-85, 2011. [Indexed in Scopus, Impact factor: 4.857]
  • Sarethy, I.P., Gulati, N., Bansal, A., Gupta, V., Malhotra, K. and Gabrani, R. “Genetic structure of an endangered Cycas evolute using RAPD markers”. Res J Biotech. Vol. 6, pp. 50-55, 2011. [Indexed in Scopus].
  • Sarethy, I.P., Saxena, Y., Kapoor, A., Sharma, S., Sharma, S.K., Gupta, V. and Gupta, S. “Alkaliphilic bacteria: applications in industrial biotechnology”. J Industrial Microbiol Biotechnol. Vol. 38(7), pp. 769-790, 2011. [Indexed in Scopus, Impact factor: 2.375]
  • Suchit, M., Shrey, K., Deepika. D., Shruti, K. and Rani, V. “Air pollutants: The key stages in the pathway towards the development of cardiovascular disorders”. Env Toxicol Pharmacol. Vol. 31, pp. 1-9, 2011. [Indexed in Scopus, Impact factor: 1.425]
  • Ahuja, S., Kohli, S., Krishnan, S., Dogra, D., Sharma, D. and Rani, V. “Curcumin: a potential therapeutic polyphenol prevents noradrenaline-induced hypertrophy in rat cardiac myocytes”. J Pharm Pharmacol. Vol. 63(12), pp. 1604-1612, 2011. [Indexed in SCOPUS, Impact factor : 1.918]
  • Banerjee, K., Gupta, U., Gupta, S., Wadhwa, G., Gabrani, R.,Sharma, S.K. and Jain, C.K. “Molecular docking of glucosamine-6-phosphate synthase in Rhizopus oryzae”. Bioinformation. Vol. 7(6), pp. 285-290, 2011. [Impact factor: 1.15]
  • Banerjee, K., Gupta, U., Gupta, S., Sharma, S.K. and Jain, C.K. “Functional Coevolutionary study of glucosamine-6-phosphate synthase in mycoses causing fungi”, Bioinformation. Vol. 7(1), pp. 10-13, 2011. [ Impact factor: 1.15]
  • Gupta, U., Banerjee, K., Gabrani, R.,Gupta, S.,Sharma, S.K. and Jain, C.K. “Variability analyses of functional domains within glucosamine-6-phosphate synthase of mycoses-causing fungi”. Bioinformation. Vol. 6(5), pp. 196-199, 2011. [Impact factor: 1.15]
  • Jaiswal, A., Chhabra, A., Malhotra U., Kohli, S. and Rani, V. “Comparative analysis of human matrix metalloproteinases: emerging therapeutic targets in diseases”. Bioinformation. Vol. 6(1), pp. 23-30, 2011. [Impact factor: 1.19]
  • Kumar, P.M., Saluja, S., Pant, M., Rachana. and Jain, C.K. “Docking studies to investigate interactions of vasicine molecule with oxidative enzymes”. J Pharm Res. Vol. 4(11), pp. 3907-3909, 2011. [Impact factor 2.36]
  • Dogra, D., Ahuja, S., Krishnan, S., Kohli S., Anand, R. and Rani, V. “Phytochemical screening and antioxidative activity of aqueous extract of Indian Camellia sinensis”, J Pharm Res. Vol. 4(6), pp.1833-1835. 2011. [Impact factor 2.36]
  • Dogra, D., Ahuja, S., Krishnan, S., Kohli, S. and Rani, V. “In vitro cardioprotective effect of indian Camellia sinensis extract against hydrogen peroxide induced hypertrophy”. J Pharm Res. Vol. 4(6), pp.1877-1879, 2011. [Impact factor 2.36].
  • Jaiswal, A., Chhabra, A., Malhotra, U., Kohli, S. and Rani, V. “Comparative analysis of human matrix metalloproteinases: Emerging therapeutic targets in diseases”. Bioinformation. Vol. 6(1), pp. 23-30, 2011.
  • Dogra, D., Ahuja, S., Krishnan, S., Kohli, S. and Rani, V. “In vitro cardioprotective effect of evolu Camellia sinensis extract against hydrogen peroxide induced hypertrophy”. J Pharm Res. Vol. 4(6), pp. 1877-1879, 2011.
  • Atale, N., Jaiswal, A., Chhabra, A., Malhotra, U., Kohli, S., Mohanty, S. and Rani, V. “Phytochemical and antioxidant screening of Syzygium cumini seed extracts: A comparative study,” J Pharm Res. Vol. 4(12), pp. 4530-4532, 2011. [Impact factor 2.36]
  • Dogra, D., Ahuja, S., Krishnan, S., Kohli, S., Ramteke, A., Atale, N. and Rani, V. “Phytochemical screening and antioxidative activity of aqueous extract of Indian Camellia sinensis,” J Pharm Res. Vol. 4(6), pp.1833-1835, 2011. [ Impact factor 2.36]
  • Chhabra, A., Jaiswal, A., Malhotra, U. and Rani V. “Effect of curcumin on matrix metalloproteinases screened in norepinephrine induced cardiac hypertrophy”. J Comput Intel Bioinformat. Vol. 4(1), pp 1-10, 2011.
  • Mohanty, S., Rawal, S, Singh, P. and Gupta, A. “Curcumin longa and Emblica officinalis increase lifespan in Drosophila melanogaster”. Dros Inf Serv. Vol. 94, pp 122-125, 2011.

2010

  • Neha, S., Rani, V. and Goswami, S.K. “Isolation and characterization of developmentally regulated novel target site from embryonic chick heart”. African J Biotechnol. Vol. 9(17), pp. 3699-3713, 2010. [Indexed in Scopus, Impact factor: 0.6]
  • Mishra, A.K., Jain, C.K., Agarwal, A., Jain, S., Jain, K.S., Dudha, N., Mehta, K., Sharma, S.K. and Gupta, S., CHIKVPRO – a protein sequence annotation database for Chikungunya Virus. Bioinformation. Vol. 5(1): 4-6, 2010. [Impact factor: 0.5]
  • Richa, G., Neha, S., Purbasa, P., Ishita, S., Rahul, S., Rawal, K. and Rani, V., “High AU content: a signature of upregulated miRNA in cardiac diseases”. Bioinformation. Vol. 5(2), pp. 132-135, 2010.

2009

  • Kohli, S., Ahuja, S., Malhotra, N. and Rani, V. “RNA interference: Emerging diagnostics and therapeutics tool”. Biochem Biophysic Res Commun. Vol. 38, pp. 273–277, 2009. [Indexed in Scopus, Impact factor: 2.648]
  • Neha, S. and Rani, V. “The genetic blue print of heart development”. Res Jof Biotechnol. Vol. 4(3), pp. 68-71, 2009. [Indexed in Scopus]

2008

  • Schug, M., Baines, J., Killon-Atwood, A., Mohanty, S., Das, A., Smith, S., Shiva, Z., McEvey, S. and Stephan, W. “Evolution of mating isolation between populations of Drosophila ananassae”. Mol Ecol. Vol. 17(11), pp. 2706-2721, 2008. [Indexed in Scopus, Impact factor: 5.84]
  • Oswal, N., Sahni, N.S., Bhattacharya, A., Komath, S.S. and Muthuswami, R. “Unique motifs identify PIG-A proteins from glycosyltransferases of the GT4 family”. BMC Evol Biol. Vol. 8(1), pp. 1-14, 2008. [Indexed in Scopus]

2007

  • Jain, C. K. and Vishwanathan, N. “Parkinson’s disease: A perilous magic of nature”. Scientific Res Essay. Vol. 2(7), pp 251-255, 2007.
  • Mohanty, S. and Pandey, D. “Amplification of orthologous DNA fragments in three Drosophila species endemic to India”. Dros Inf Serv. Vol. 90, pp. 113-114, 2007.
  • Mohanty, S. and Pandey, D. “Multilocus nuclear DNA markers for population genetic study in Drosophila malerkotliana”. Dros Inf Serv. Vol. 90, pp. 115-116, 2007.

Book: Rani V., Singh U.C. (Eds.), Free Radicals in Human Health and Disease, Springer, 2015, ISBN 978-81-322-2035-0

Book Chapters:

  • S. Dhaliwal, P. Nag, R. Rajput, S. Kumar, M. Singh, Escitalopram loaded nanoparticles; preparation and effect of formulation variables on encapsulation efficiency, Nanotechnology: Novel Perspectives and Prospects”,being published by M/S McGraw Hill, USA.
  • M. Singh, S. Malik and G. Mathur, “Comparative analysis of Antimicrobial and antioxidant potential of Ginkgo biloba (EGb 761) microemulsions and Ginkgo biloba extract (EGb 761)” In “Industrial, medical and environmental applications of microorganisms: current status and trends” Editor: A. Méndez-Vilas. Wageningen Academic Publishers. ISBN Print version: 978-90-8686-243-6, ISBN E-book: 978-90-8686-795-0, pg 517 – 520, 2014.
  • S. Gupta, V. Gupta, S. Aggarwal and P. Diwan, E- Lesson- “General Acccount of Bacterial Cell Organization’’ for Institute of LifeLong Learning, University of Delhi, Virtual learning Environment 2014.http://vle.du.ac.in/mod/tab/view.php?id=9778; https://docs.google.com/file/d/0B0Izh6GcIA_DmnBka 2JBTUZhZjQ/edit?pli=1
  • S. Rajasekharan and S. Gupta, “Bioinformatics based approaches to study virus-host interactions during Chikungunya virus infection” in Chikungunya virus in Methods in Molecular Biology, published by Springer (Accepted) 2015.
  • N. Dudha and S. Gupta, “Viral-Host protein interaction studies using Yeast two-hybrid screening method” in Chikungunya virus in Methods in Molecular Biology, published by Springer (Accepted) 2015.
  • Mani, S. Production of Reactive oxygen species and its implication in human diseases. Free radicals in human health and disease. Springer, 2015, ISBN 978-81-322-2035-0, 2015.
  • Reema Gabrani. “Cancer biology and RNAi” inModern Biotechnology and its applications Part 2.Kambaska Behera, New India Publication Agency, N. Delhi, India. pp. 513-542. 2013.
  • Agrawal, A., Dang, S. and Gabrani, R. “Recent Advances in Anti-Telomerase Cancer Therapy” In “Topics in Anti-Cancer Research” Volume 3, Ed Atta-ur-Rahman and K. Zaman; Bentham Science Publishers, chapter 16, pp. 581-631. ISBN: 978-1-60805-909-6, 2014.
  • Aastha Chhabra, Shrey Kohli, Vibha Rani, “MMPs in Cardiovascular Diseases: Emerging Pharmacological Targets” in Role of Proteases in cellular dysfunction, Springer New York, pp. 407-426, 2014.
  • Vibha Rani, Mainak Chakraborty, Arushi Jain, “Nanobiotechnology: a promising approach for the pathogenic sensing” in Recent Trends in Microbial Biotechnology, Lambert Academic Publishing House pp. 17-36, 2010.
  • Rani, V.,Indira, P.S., Diksha, G., Karthikeya, T., Mayank, C. and Neha, S. “Defense signaling pathways in Arabidopsis thaliana: a model host plant to study plant pathogen interactions”- ‘Advancement of Biotechnology’, International Book Distributing Co., Lucknow, India, 2011.
  • Gupta, V. and Gupta, S. Diversity of Microbial World: General Microbiology (chapter in e-book), http://nsdl.niscair.res.in /bitstream /123456789/137/2/ Diversity_MicrobialWorld.doc Book is part of Council of Scientific and Industrial Research (CSIR), Government of India, initiative as core book for the first year undergraduate students spread all over the country, 2008.

Patent filed: Sudha Srivastava and Shikha Sharma (2010) “Novel process to enhance thermal stability of enzyme nanoparticles” Indian Patent Application No 2782/DEL/2010. Filing date: 23-11-2010

NCBI/ GEO submissions: Total 06

Yashika Rustagi, Vibha R, MiroRNA profiling dataset from chick heart libraries, 2015

  • GSM1705503 Gallus gallus_CHL1_JIIT4DS1_HH24
  • GSM1705504 Gallus gallus_CHL2_JIIT6DS1_HH29
  • GSM1705505 Gallus gallus_CHL3_JIIT8DS1_HH34
  • GSM1705506 Gallus gallus_CHL4_JIIT10DS1_HH36
  • GSM1705507 Gallus gallus_CHL5_JIIT12DS1_HH38
  • GSM1705508 Gallus gallus_CHL6_JIIT14DS1_HH40

Gene Bank Submissions: Total 12

  • 1.“Full-length cloned sequence of the non-structural protein 1 (nsP1) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak.”Genbank Accession No. JF272473, 2011.
  • 2.“Full-length cloned sequence of the non-structural protein 2 (nsP2)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak.” Genbank Accession No. JF272474, 2011.
  • 3.“Full-length cloned sequence of the non-structural protein 3 (nsP3)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak. “ Genbank Accession No. JF272475, 2011.
  • 4.“Full-length cloned sequence of the non-structural protein 4 (nsP4)gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak.” Genbank Accession No. JF272476, 2011.
  • 5.“Full-length cloned sequence of the capsid protein gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak.” Genbank Accession No. JF272477, 2011.
  • 6.“Full-length cloned sequence of the Envelope protein 3 (E3) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak.” Genbank Accession No. JF272478, 2011.
  • 7.“Full-length cloned sequence of the Envelope protein 2 (E2) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak.” Genbank Accession No. JF272479, 2011.
  • 8.“Full-length cloned sequence of the Envelope protein 1 (E1) gene of Chikungunya virus, isolate IND-06-Guj, of 2006 outbreak.” Genbank Accession No. JF272480, 2011.
  • 9.“Full-length cloned sequence of the 6K gene of Chikungunya virus,isolate IND-06-Guj, of 2006 outbreak.” Genbank Accession No. JF272481, 2011.
  • 10. V. Rani. Cardiac 1: 72 hours embryonic chick cardiac cDNA Expression library, EST sequence; Genbank Accession No. GW691607, March 17, 2010.
  • 11. V. Rani, D. Gupta, A. Gupta. Cardiac 2: 72 hours embryonic chick cardiac cDNA Expression library, EST sequence, Genbank Accession No. GW868518, May 3, 2010.
  • 12. V. Rani, D. Gupta, A. Gupta. Cardiac 3: 72 hours embryonic chick cardiac cDNA Expression library, EST sequence, Genbank Accession No. GW883522, May 11, 2010.

6. Details of collaborations, if any.

S. No. Name of the collaborator Organization
1. Prof. Vijay K. Chaudhary Professor and Head, Department of Biochemistry, University of Delhi South Campus (UDSC)
2. Prof. Sudhanshu Vrati Dean, Translational Health Science & Technology Institute, (THSTI)
3. Dr. Dinesh Gupta Research Scientist, International Centre for Genetic Engineering and Biotechnology (ICGEB)
4. Dr. Amita Gupta Associate Professor, Department of Microbiology, Univ. of Delhi, South Campus
5. Dr. Manish Sharma Research Scientist, Defence Institute of Physiology and Allied Sciences (DIPAS), Delhi
6. Dr Shyamal K Goswami Professor, School of Life Sciences, JNU
7. Dr. Punit Kaur Professor and Head, Department of Biophysics, All India Institute of Medical Sciences, Delhi
8. Prof Malcolm Schug Associate Professor and Director of Undergraduate Studies, Univ. of North Carolina, Greensboro
9. Dr. Aparup Das Scientist E, National Institute of Malaria Research, ICMR, New Delhi
10. Prof. K. K. Biswas/ Yamuna Prasad Department of Computer Science and Engineering, IIT Delhi
11. Dr. Gulshan Wadhwa Joint Director, Dept. of Biotechnology, Govt. of India
12. Dr. R.T. Narendhirakannan Assistant Professor (SG), Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Coimbatore
13. Dr. UmeshC. S. Yadav Assistant Professor and Coordinator, School of Life Sciences, Central University of Gujarat
14. Dr Javed Ali Senior Assistant Professor, Department of Pharmaceutics, Jamia Hamdard, New Delhi.
15. Prof. Dr. John Baines Professor, Max Plank Institute for Evolutionary Biology, Germany
16. Dr. S. P. Singh Associate Prof., Dept. of Biochemistry, Banaras Hindu University (BHU), Varanasi

(v) Research area, brief on Research activities, abstract of research work

Sanjeev K. Sharma, Ph.D., DIC

Research area: Regulatory peptide and Bioinformatics

Brief on Research activities:

Quality data is key considerations in drug development process; providing evidence to support a drug or biologic product efficacy and safety. To address heterogeneity in CDM (clinical database management) systems and deficits in quality management of data in clinical trials, performance metrics representing critical CDM procedural steps are being developed to meet data quality in compliance of GCP and ready for regulatory submission.

In parallel proof of concept studies an unexploited aspect of brain-gut peptides NMU and NMS is being explored seeking to understand its potential role in disorders of pregnancy.

Sanjay Gupta, Ph.D.

Research area : Viral diseases and Functional Genomics

Brief on Research activities:

Newly emerged and re-emerged diseases in the recent past caused by SARS, Chikungunya (CHIKV), Chandipura (CHPV), Bird flu and other viruses have amply highlighted the vulnerability of developing and developed nations.. Research is being carried out on emerging/re-emerging pathogens specifically CHPV, endemic to India with 70% mortality among children and CHIKV with its annual large scale outbreaks in the country since 2006 when it infected ~1.6 million individuals. The on-going research objectives are to understand the molecular and cell biology of pathogen-host-vector interactions in these diseases; study the pathogen specific remodeling processes of the host/vector cell; identify interactions which could be target for therapeutics and identify peptide based inhibitors.

Vibha Gupta, Ph.D.

Research area : Structural Biology

Brief on Research activities:

In view of the rapid pace with which multidrug resistant strains of almost all group of pathogens are emerging, the need for new antibacterial compounds cannot be overemphasized. Research efforts have been initiated for early-stage rational drug discovery for a novel antimicrobial agent(s). Determination of X-ray crystal structure of a potential drug target from human pathogens responsible for infecting respiratory and/or gastrointestinal tract is on-going. The availability of the 3D – structural information of a drug target from many pathogenic organisms will enable the possibility of rational structure-based design and development of both a broad-spectrum and conversely, a pathogen-specific drug molecule.

Sudha Srivastava, Ph.D.

Research area : Diagnostic devices – Nanotechnology; Biosensors

Brief on Research activities:

The increasing demand for early diagnosis, sensitive and easy detection of the most threatening disease at curable state is the major driving force behind development of novel approaches for disease diagnostic tool. Nanoparticles are exploited for development of biosensors with improved stability, sensitivity and response time. A nanoparticle based glucose biosensor has been developed and investigations are ongoing for thyroid biosensor as well as immunosensor for cancer diagnosis as point of care device development.

Vibha Rani, Ph.D.

Research area : Medical Biotechnology

Brief on Research activities:

Heart development is a highly conserved process across all vertebrate organisms. MicroRNAs (miRNAs), the non-coding RNAs are researched extensively due to their newly found role as regulators of gene expression in developmental processes. Emerging evidences suggest that specific spatio-temporal miRNA expression is required for proper embryonic developmental processes such as cardiogenesis, myogenesis, hematopoisis and neurogenesis. These small RNAs are the critical regulator of differential gene expression. When, how and where they are expressed during the various stages of heart development is the objective of ongoing research that will increase understanding of gene regulation during vertebrate heart development and diseases.

Reema Gabrani, Ph.D.

Research area : Protein Engineering

Brief on Research activities:

Current research interests include exploring the anti-microbial and anti-proliferative aspects of plant active compounds & antimicrobial peptides and their nano-encapsulated forms to understand the scientific basis of their activity which could lead to the development of unique drugs. Also part of studies on protein based interactions of Chandipura and Chikungunya virus with viral and host factors to understand the pathogenesis and disease progression. Notably such work can lead to the generation of novel therapeutic strategies.

Sujata Mohanty, Ph.D.

Research area : Molecular Genetics and Genomics

Brief on Research activities:

Drosophila has clearly evolved as a model organism for a wide array of genetic studies. With recent development in genomic applications in biomedical and agricultural research, initial information also has come from studies with Drosophila model. The comparative genomics of many sequenced genomes was quite surprising; many of the genes identified in D. melanogaster were found to be conserved across other organisms including human. Presently, the whole genome sequence of 12 different Drosophila species is publicly available in the databases, providing baseline to understand how genomes have evolved. India is rich in biological diversity with many flora and fauna present in many eco-climatic zones. Inferring genetic inter-relationship among closely related species is not only important for academic point of view but also to understand how species diversity has been accompanied by small changes at the nucleotide level. Since Drosophila has shown ways in understanding genetic and biology of many organisms including human, studying the evolution of insecticide resistant, behaviour genes and cold adapted genes, effect of mutagenesis and understanding aging process is the focus of present research work which may well be utilized in other organisms of agriculture (insect pest) and health concern.

Shweta Dang, M. Pharm, Ph.D.

Research area : Novel Drug Delivery systems

Brief on Research activities:

Polymeric Nanoparticles (chitosan, PLGA) containing encapsulated, dispersed, absorbed drugs are being investigated to improve the delivery and bioavailability of some anti epileptic drugs, anti alzheimer’s drugs and for some other CNS related disorders. Nanoemulsions encapsulating some natural antimicrobial compounds (catechins and flavanoids) are being investigated for enhanced efficacy and bioavailability. These nano carriers help improve the stability of hydrophobic drugs, rendering them suitable for administration, improving biodistribution and pharmacokinetics, resulting in improved efficacy, reduction in adverse effects because of less peripheral circulation and decreasing toxicity by using biocompatible and biodegradable nanomaterials.

Chakresh Jain, M.Sc., MCA, ALCCS (eqvt. M. Tech-CS), Ph.D.

Research area : Bioinformatics

Brief on Research activities:

Research group focuses on the development of pathogenic microbial network specially Bacillus anthracis ames and Aspergilus fumigates Af293 and identification of potential drug target using computational methods such as machine learning and phylogenetic profiling and tools. Work is being carried out for new algorithms and pipelines for computational si/miRNA designing, novel antimicrobial peptide identification and database creation on microbial pathogens. Further in-silico target-ligand interactions and simulation studies are also conducted for the investigation of neuaroprotective potentials of medicinal plant compounds from selected medicinal plants.

Kamal Rawal, Ph.D.

Research area : Bioinformatics

Brief on Research activities:

Diseases such as obesity and its induced disorders such as type 2 diabetes have complex pathophysiology which includes role of candidate genes, proteins, metabolic pathways, mobile genetic elements etc. The research group construct networks of complex systems, does data mining & pattern recognition, implement machine leaning systems, and develop sophisticated tools and pipelines to solve problems relevant to disease biology. In addition the group has discovered and modeled complex biological signals through which mobile genetic elements insert in an integration site in the genome & may cause cancer and other diseases. Similar signals are being investigated at promoters and splice sites. Analysis of over 50 genomes including human, mouse, monkey, and plants are being underway.

Shalini Mani, Ph.D.

Research area : Medical Biotechnology

Brief on Research activities:

Mitochondria, being a powerhouse of the cellular system are a most important organelle. Hence, any perturbation in mitochondrial metabolism may affect several organs and hence cause several diseases/disorders. In the last few decades only, mitochondrial defects are found to be associated with a large number of metabolic and neurological disorders. Based on it, the current research interest is to explore the mechanism of pathogenic role of mitochondria in common metabolic/lifestyle diseases like cancer and diabetes.

Research is also being conducted to explore the possible mechanism behind the association between vitamin D deficiency and pathogenesis of type 2 diabetes.

Priyadarshini, Ph.D.

Research area : Medical Biotechnology

Brief on Research activities:

Kidney stone formation is a complex process involving multiple factors. It invariably comprises a combination of inorganic crystals and organic macromolecules consisting principally of proteins, lipids and glycominaglycans. It has been assumed that inhibitors of urolithiasis have protective effect while stimulator helps in stone formation. The inhibition is generally understood to arise mainly from the non-dialyzable molecules of urine, particularly acidic glycoproteins and glycosaminoglycans. Some inhibitor as well as stimulator molecules have been identified, including Tamm–Horsfall protein, uropontin, calgranulin, bikunin, and prothrombin F1 fragment. Interaction of biomolecules present in kidney stone is being investigated so as to solve the mystery of stone formation.

13. Manisha Singh, M. P. T (Neurology), CNDT, PhD (Ongoing)

Research area: Novel Drug Delivery systems

Brief on Research activities:

The main difficulty to treat CNS disorders is to deliver the drug at site as, the complex anatomy of the brain and “blood brain barrier” put a restriction to most of the molecule to cross and reach inside the brain. Nasal route is chosen for drug delivery as it can cross the olfactory pathway by one or a combination of pathways. We aim to develop a drug delivery system which shows site specificity in case of Central Nervous System Disorders (CNS Disorders) like Alzheimer’s disease, Epilepsy, Psychosomatic disorders etc., which can reduce the dose, adverse effects and can enhance rate and extent of drug transport. Polymeric nanoparticles by different methods (ionic gelation, Coacervation etc.) were explored to encapsulate various plant based medicinal (Gingko biloba, Catechin hydrate, etc.) and drugs (Gabapentin, Escitalopram, hydrochlorothiazide) compounds. Further, their characterizations and in vitro toxicity and safety evaluation are been done on cellines (NB41A3, RPMI2650, Vero etc). These nanoformulation help in increasing the efficacy, bioavailability and stability of these compound and make them more therapeutically potential.