BIOGRAPHY

Dr. Shalini Mani is Associate Professor in the Department of Biotechnology at Jaypee Institute of Information Technology, Noida, India. She has total 17 years of research and 10 years of teaching experience. She completed her PhD from Centre for Cellular and Molecular Biology, Hyderabad, where she worked on detailed analysis of clinical biochemical and genetic analysis of Leigh syndrome patients and found an interesting geneotype-phenotype correlation of mitochondrial and nuclear gene mutations in these patients. She did her post-doctorate from Murdoch Children Research Institute, Melbourne Australia. During her post doctorate, she has been awarded with one of the prestigious award of Endeavor Research fellowship, Australia. She did her post-graduation from G B pant University, Pantnagar in Molecular Biology and Genetic Engineering. Throughout this period, her research work has fetched in to several publications in international journals of high repute.

Dr Mani is primarily involved in studying the role of mitochondria in different chronic diseases and effect of different environmental factors on mitochondrial metabolism. As a translational researcher, she is also exploring the molecular mechanism for therapeutic benefits of some selected herbs on mitochondrial activity in different diseases conditions such as diabetes and cancer.

RESEARCH HIGHLIGHTS

Mitochondria, being a powerhouse of the cellular system are a most important organelle. Along with ATP generation it also helps in removal of oxidative stress from the system. Hence, any perturbation in mitochondrial metabolism may affect several organs and hence cause several diseases/disorders. In the last decade only, research based on various aspects of mitochondria started coming in to the picture. As result of which mitochondrial defects are suggested to be associated with a large number of metabolic and neurological disorders.  However, the research exploring the detailed mechanism of participation of mitochondria, it’s possible defects etc in causation and or progress of the large number of diseases are still in infancy. Hence, currently my primary research interest is to explore the mechanism of pathogenic role of mitochondria in common metabolic diseases like cancer and diabetes. To understand the same, my lab is  mainly focusing on, bioenergetics of cell system, redox imbalance, mitochondrial genome instability, copy number variation of mtDNA, its possible genetics and mitochondrial- nuclear cross talk during cancer and diabetes.

Our group is also exploring the therapeutic potential of several herbs, known to be rich in potential anti-cancerours natural compounds. Some of these herbs may target the mitochondria of cancerous cells and termed as herbal mitocans. We are aiming to study these herbs and their natural compounds for their anti-proliferative and mitochondria targeting ability using different in-silico (molecular docking and simulation) and in-vitro assays.

PUBLICATIONS

RESEARCH ARTICLES

• Geeta Swargiary, Shalini Mani. Nanotubes and Fullerene as Efficient Nanocarriers for Delivery of Mitocans to Hexokinase 2: An In-silico Approach. Materials Today Proceedings,2022. (Accepted, IF. - 1.6)
• Rupesh Kumar, Manisha Singh, Shalini Mani, Rachana, Md. Malik, Kabalarian Ponnusamy and Shazia Haider, “Amyotrophic Lateral Sclerosis risk genes and suppressor", Current Gene Therapy, Bentham Science, September 2022. (Accepted, IF. - 2.43)
• Manisha Singh, Vinayak Agarwal, Divya Jindal, Pranav Pancham,
• Shriya Agarwal, Shalini Mani, Raj Kumar Tiwari, K. Das, Badrah S. Alghamdi,
• Turki S Abujamel, Ghulam Md. Ashraf, Saurabh Kumar Jha. Recent updates on Corticosteroids induced neuropsychiatric disorders
• and its theranostic advancements through Gene editing tools. Diagnostics, Oct 2022. (I.F- 3.99).
• Shalini Mani, Divya Jindal, Hitesh Chopra, Saurabh Kumar Jha, Sachin Kumar Singh, Gulam Md Ashraf, Mehnaz Kamal, Danish Iqbal, Dinesh Kumar Chellappan, Abhijit Dey, Saikat Dewanjee, Keshav K Singh, Shreesh Ojha, Inderbir Singh, Rupesh K. Gautam, Niraj Kumar Jha, ROCK2 Inhibition: A Futuristic Approach for the Management of Alzheimer’s Disease. Neuroscience & Biobehavioral Reviews, 2022, 104871, (IF. - 9.01). https://doi.org/10.1016/j.neubiorev.2022.104871.
• Yadav, Deepshikha, Shriya Agarwal, Pranav Pancham, Divya Jindal, Vinayak Agarwal, Premshankar Kumar Dubey, Saurabh K. Jha, Shalini Mani, Rachana, Abhijit Dey, Niraj Kumar Jha, Kavindra Kumar Kesari, and Manisha Singh. Probing the Immune System Dynamics of the COVID-19 Disease for Vaccine Designing and Drug Repurposing Using Bioinformatics Tools. Immuno 2022, 2, 344-371. https://doi.org/10.3390/immuno2020022.
• Shalini Mani*, Divya Jindal, Manisha Singh. Gene Therapy, A potential Therapeutic Tool for Neurological and Neuropsychiatric Disorders: Applications, Challenges and Future Prospective.  Current Gene Therapy, 2022. (IF. - 4.39) doi: 10.2174/1566523222666220328142427.
• Niraj Kumar Jha†, Wei-Chih Chen†, Sanjay Kumar†, Rajni Dubey, Lung-Wen Tsai, Rohan Kar, Saurabh Kumar Jha, Piyush Kumar Gupta, Ankur Sharma, Rohit Gundamaraju, Kumud Pant, Shalini Mani, Sandeep Kumar Singh, Ricardo B. Maccioni, Tirtharaj Datta, Sachin Kumar Singh, Gaurav Gupta, ParteekPrasher, Kamal Dua, Abhijit Dey, Charu Sharma, Yasir Hayat Mughal, Janne Ruokolainen, Kavindra Kumar Kesari and Shreesh Ojha. Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review. Open Biology, 2022, 12 (3), 210289 (IF. - 5.9) doi/10.1098/rsob.210289.
• Geeta Swargiary, Shalini Mani*. ER and PGR Targeting Ability of Phytocompounds Derived from Centella asiatica and Andrographis paniculata: An In-silico Approach. J of Herbal Medicine. Volume 32, March 2022, 100541 (I.F.- 3.03) https://doi.org/10.1016/j.hermed.2022.100541
• Niraj Kumar Jha, ShanuBhardwaj; Kavindra Kumar Kesari, Mahesh Rachamalla, Shalini Mani, Dinesh Kumar Chellappan, Sachin Kumar Singh, Kamal Dua, JanneRuokolainen, Mohammad Amjad Kamal, ShreeshOjhaCRISPR/ Cas9 gene editing: A shining beacon of hope in Alzheimer's therapeutics. JAdv Res, 2021. https://doi.org/10.1016/j.jare.2021.07.001 (IF, 10.47)
• Shalini Mani*, Geeta Swargiary, Sasha Gulati, Simmi Gupta.Molecular Docking and ADMET Studies to Predict the Anti-Breast Cancer Effect of Aloin by Targeting Estrogen, and Progesterone Receptors.Materials Today Proceedings, 2021 doi: 10.1016/j.matpr.2021.06.362 (Accepted).
• Shalini Mani^*, Geeta Swargiary, Sakshi Tyagi, Manisha Singh, Niraj Kumar Jha^, Keshav K Singh. Nanotherapeutic Approaches to Target Mitochondria in Cancer. Life Sciences 281 (2021) 119773. (IF, 5.03)
• Manisha Singh, Shriya Agarwal, Pranav Pancham,  , Harleen Kaur, Vinayak Agarwal, Ramneek Kaur, Shalini Mani. In silico validation and fabrication of matrix diffusion based polymeric transdermal films for repurposing gabapentin hydrochloride in oncogenic neuropathic pain. BioRxiv, doi: https://doi.org/10.1101/2020.12.01.406041.
• Shalini Mani*,Geeta Swargiary andRadhikaChadha. Mitophagy Impairment in Neurodegenerative Diseases: Pathogenesis and Therapeutic Interventions. Mitochondrion 57 (2021) 270–293.(IF, 4.9)
• Shalini Mani*, GeetaSwargiary and Keshav K Singh. Natural Agents Targeting Mitochondria in Cancer Int.J. Mol. Sci. 2020, 21, 6992; doi:10.3390/ijms21196992
• Shalini Mani*.Mitochondrial Epigenetics: An Unnoticed Phenomenon of Mitochondrial Gene Expression. Polymorphisms, 2020; 5: 53-67.
• Manisha Singh, Surinder P. Singh, Deepshikha Yadav, Mugdha Agarwal, Shriya Agarwal_, Vinayak Agarwal, GeetaSwargiary, Sahil Srivastava, SakshiTyagi, Ramneek Kaur, Shalini Mani^*.Targeted delivery for neurodegenerative disorders using gene therapy vectors: Gen next therapeutic goals, Current Gene Therapy. August 2020. DOI: 10.2174/1566523220999200817164907
• Manisha Singh, Surinder P Singh, Premshankar K Dubey, Rachana, Shalini Mani,Deepshikha Yadav, Mugdha Agrawal, Shriya Agarwal, Vinayak Agarwal, Harleen Kaur. Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer’s Disease" in special issue “Neuroproteomics on rise” in Current Protein & Peptide Science June 2020. doi: 10.2174/1389203721666200615173213
• Shalini Mani*, G R Chandak, Keshav K Singh, Rajender Singh^, S Narasimha Rao. Novel p.P298L SURF1 mutation in thiamine deficient Leigh syndrome patients compromises cytochrome c oxidase activity. Mitochondrion 2020, 53: 91–98
• Shalini Mani*, S. Narasimha Rao, M V Kranthi Kumar. G6036A substitution in mitochondrial COX I gene compromises cytochrome c oxidase activity in thiamine responsive Leigh syndrome patients. J Neurol Sci.415 (2020) 116870.
• Shalini Mani*. “Letter to the editors" in regard to the article 'Genetic heterogeneity of mitochondrial genome in thiamine deficient Leigh syndrome patients’ J NeurolSci, 2019, 407;116441
• Shalini Mani*, S. Narasimha Rao, M V Kranthi Kumar. Genetic Heterogeneity ofMitochondrial Genome in Thiamine Deficient Leigh Syndrome Patients. J NeurolSci 404, pp 91–100, 2019
• GeetaSwargiary, Aarushi Singh, Sahil Srivastava, Shalini Mani*. Metformin: A Future Anticancerous Drug. Research Reports.  doi:10.9777/rr.2018.10337, 2018
• NishthaSaxena, Nancy Taneja, PrakritiShome, Shalini Mani*. Mitochondrial donation: A boon or curse for the treatment of incurable mitochondrial diseases. J Hum ReprodSci, 11 (1), pp 3-9, 2018.
• Negi A., Singh P.,  Taneja N., Mani S*, "Molecular-Docking Study of Anti-Stress Natural Compounds Against GABAa Receptor Portends the Novel Approach to Stress Treatment". Journal of Applied Pharmaceutical Science. 8, pp 38-43, 2018
• Nancy Taneja, Shalini Mani*.  Vitamin D status influences mitochondrial metabolic activity and hyperglycaemic condition of skeletal muscle cells. Journal of Pharmacy Research,  12(2), pp 221-226, 2018
• Nancy Taneja, Rajesh Khadgawat, Shalini Mani*. Vitamin D receptor gene polymorphisms and haplotype analysis in type 2 Diabetes Mellitus patients from North India.  Asian J Pharm Clin Res, 10(10), pp248-252, 2017
• Nancy Taneja, Rajesh Khadgawat, BaibaswataNayak, Shalini Mani*. Study of mitochondrial DNA copy number variation in peripheral blood of Type 2 Diabetes patients: A Pilot Study. Int. J. Pharm. Sci. Rev. Res., 44(2), pp 210-214, 2017.
• Nancy Taneja, Rajesh Khadgawat, Shalini Mani*. Bsm I and TaqI polymorphism in vitamin D receptor gene of Type 2 diabetes Mellitus patients from North India. Asian Journal of Pharmaceutical and clinical research. 9 (3), pp 186-189, Oct 2016
• SamikshaKukal, Nancy Taneja, Shalini Mani*. Vitamin D deficiency may affect the glucose uptake in L6 cells by affecting the mitochondrial metabolism. Int J Pharma and Bio Sci, 7(4), pp 459 – 466, 2016.
• Akshita Gupta, ShahrukhHusian, Shalini Mani*. Role of metals in Alzheimer's disease. Int. J. Life Sc. Bt& Pharm. Sci. 1(1), pp1-11, 2016.
• Nancy Taneja, Priyadarshini, Shalini Mani*. “Vitamin D receptor gene polymorphisms (TaqI) in North Indian population with type 2 diabetes. International Journal of Basic and Applied Biology, 3(1), pp 75-75, 2016.
• Nancy Taneja, SamikshaKukal, Shalini Mani*. CytB: a hot spot for pathogenic mutations in mitochondrial genome of breast cancer and ovarian cancer patients. Int J Pharm PharmSci, 7 (9), pp128-135, 2015.
• ArshpreetKalsi, Shivangi Singh, Nancy Taneja, SamikshaKukal, Shalini Mani*. Current treatments for type 2 diabetes, their side effects and possible complementary treatments. Int J Pharm PharmSci, 7(3), pp 315-318, 2015.
• RadhikaChadah, Ritika Shah, Shalini Mani*. “Analysis of reported SCO2 gene mutations affecting cytochrome c oxidase activity in various diseases”. Bioinformation, 10(6), pp329-333, 2014.
• Shanu Bhatia, Rachana, Pankaj Bansal, Shalini Mani*. Mitochondrial diabetes: Different diagnostic features and its possible management. J Int Med SciAcad, Vol.27 (4), 213--215, 2014.
• Pankaj Bansal, Shalini Mani. Immunology of Diabetes Mellitus. J Med Sci Research, 3, pp 1-2, 2012 (Editorial)
• Shilpi Aggarwal, SapnaNegi, Pankaj Jha, Prashant K. Singha, TseringStobdana, M. A. QadarPashaa, Saurabhhosh, AnuragAgrawala, Indian Genome Variation Consortium, BhavanaPrasher and MitaliMukerji. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. PNAS, USA, 107(44), pp18961–66, 2010. (Contribution in Indian Genome Variation Consortium core publications, as member of consortium).
• Shalini Mani,S Narasimha Rao, KarunaMadap, M V Kranthi Kumar, Lalji Singh, GirirajRatanChandak. High Prevalence of Infantile Encephalitic Beriberi with Overlapping Features of Leigh’s Disease. J of tropical paediatrics, 54, pp328-332, 2008.
• Genetic landscape of the people of India: a canvas for disease gene exploration. J Genet, 87, pp3–20, 2008. (Contribution in Indian Genome Variation Consortium core publications, as member of consortium).
• H.V. Raghavendra Prasad, NeelimaKharidehal, Shalini Mani, G.R. Chandak. Leigh's Syndrome: A Case Report. The Internet Journal of Pediatrics and Neonatolog, 7, 2007.
• Shalini Mani, S. Purwar, B.R. Singh, G.K. Garg and A. Kumar. Effect of Jasmonic acid on growth characteristics of calli derived from mature embryos of wheat cultivars showing differential resistance to Karnal bunt (Tilletiaindica). Plant Cell. Biotechnol. Mol. Biol., 7: 97-102, 2006.
• The Indian Genome Variation database (IGVdb): a project overview (2005). Hum Genet; 1, pp1-11, 2005. (Contribution in Indian Genome Variation Consortium core publications, as member of consortium).
• Shalini Mani,Manoj K Yadav, GoharTaj Khan, U S Singh & Anil Kumar. Enhanced proteolysis leads to pre-mature cell death under the influence of elicitor like mycelial components from Karnal bunt (Tilletiaindica) pathogen in wheat callus cultures. Indian Journal of Experimental Biology, 43, pp 746-750, 2005.

Book

• Animal Cell Culture: Principle and Practices. Author: Dr. Shalini Mani, Co-author: Dr. Manisha Singh, Dr Anil Kumar. Springer (e-proof available).2022
• ADVANCES IN BIOTECHNOLOGY AND LIFE SCIENCES. ISBN: 978-81-948426-2-0. Editor: Prof Pammi Gauba, Co-editor: Prof Sudha Srivastava, Dr. Shalini Mani. Publisher: Vidya Kutir Publications, New Delhi. 2020.

BOOK CHAPTER

• M. Singh, V. Agarwal, P. Pancham, S. Agarwal, S. Mani (2022), Exploring the Role of Statin in Reversing the Cognitive and Neurovascular Dysfunction in Dementia in book named – “Current Thoughts on Dementia – From Risk Factors to Therapeutic Interventions”; Editors: Ghulam Md. Ashraf and Md. Sahab Uddin, Springer Nature Singapore Pte Ltd., 2022 https://doi.org/10.1007/978-981- 16-7606-2_15
• M. Singh, P. Pancham, S. Agarwal, H. Kaur, V. Agarwal, R.K. Tiwari, S. Mani, Rachana (2022), Role of Immunotherapy in Ameliorating Proteopathic Dementia, in book named – “Current Thoughts on Dementia – From Risk Factors to Therapeutic Interventions”; Editors: Ghulam Md. Ashraf and Md. Sahab Uddin, Springer Nature Singapore Pte Ltd. 2022. https://doi.org/10.1007/978-981- 16-7606-2_16.
• DRUG INDUCED OXIDATIVE STRESS AND CELLULAR TOXICITY. Shalini Mani*¹, Sakshi Tyagi¹, Km Vaishali Pal¹, HimanshiJaiswal ¹, Anvi Jain¹, Aaru Gulati¹, Manisha Singh¹ (2021).Free Radical Biology and Environmental Toxicity. Editor: Kavindra Kumar Kesari, Niraj Kumar Jha. Springer Nature.
• OXIDATIVE STRESS: A POTENTIAL LINK BETWEEN PESTICIDE EXPOSURE AND EARLY-LIFE NEUROLOGICAL DISORDERS. Shalini Mani*¹, Anvi Jain^1#, Aaru Gulati^1#, Sakshi Tyagi¹, Km Vaishali Pal¹, Himanshi Jaiswal¹, Manisha Singh¹ (2021).Free Radical Biology and Environmental Toxicity. Editor: Kavindra Kumar Kesari, Niraj Kumar Jha. Springer Nature.
• Vinayak Agarwal¹, Divya Jindal¹, Shriya Agarwal¹, Shalini Mani¹, Manisha Singh^1*, Initiation of neurodegenerative disorders (NDDs) through metal toxicity generated oxidative stress. Free Radical Biology and Environmental Toxicity. Editor: Kavindra Kumar Kesari, Niraj Kumar Jha. Springer Nature
• Shalini Mani*, GeetaSwargiary, Manish Singh, MahimaRawal (2020). Mitophagy Impairment as Culprit of Alzheimer Diseases: Cellular and Molecular Mechanisms of Pathogenesis: Frontiers in Dementia Research: From Risk Factors to Therapeutic Interventions.  Editor:Md. Sahab Uddin. Springer Nature Singapore (Accepted)
• Manisha Singh, Vinayak Agarwal, Pranav Pancham, Shriya Agarwal, Siddhi Bhardwaj, Shalini Mani (2020). Possible Role of Statins in Reversing the Cognitive and Neurovascular Dysfunctions in Dementia. Frontiers in Dementia Research: From Risk Factors to Therapeutic Interventions.  Editor:Md. Sahab Uddin. Springer Nature Singapore (Accepted)
• Manisha Singh, Pranav Pancham, Shriya Agarwal, Harleen Kaur, Vinayak Agarwal, Raj Kumar Tiwari, Shalini Mani,Rachana (2020). Role of Immunotherapy in Ameliorating Proteins Accumulation Associated With Dementia in Dementia. Frontiers in Dementia Research: From Risk Factors to Therapeutic Interventions.  Editor:Md. Sahab Uddin. Springer Nature Singapore (Accepted)
• Geeta Swargiary, Mahima Rawal Manisha Singh, Shalini Mani*. (2019). Molecular Approaches to Screen Bioactive Compounds from Medicinal Plants: Plant-derived Bioactives; Production, Properties and Therapeutic Applications. Editors: Swamy, Mallappa Kumara (Ed.). ISBN 978-981-15-1761-7(e-book).Springer Nature Switzerland AG.

• Shalini Mani*, Aarushi Singh. Aging, Oxidative Stress and Antioxidants (2018).“Oxidative Stress and Antioxidant Defence: Biomedical Value in Health and Diseases” Nova Publisher, USA   ISBN: 978-1-53615-687-4.

• Shalini Mani*, GeetaSwargiary, Sahil Srivastava. Appraisal of Medicinal Plants for Anticancer Properties (2018). Phytocompounds: From sources to bioactivities and applications".Editor Mallappa Kumara Swamy and GudepalyaRenukaiahRudramurthy. ISBN 978-93-85046-43-8. Publisher Studium Press (India) Pvt. Ltd

• Shalini Mani*, ChahatKubba, Tanya Sharma, Manisha Singh. Drugs Used in the Treatment of Amyotrophic Lateral Sclerosis. (2018). “Advances in Neuropharmacology: Drugs and Therapeutics”. Publisher Apple Academic Press (Taylor and Francis). Editors: Md. Sahab Uddin, RPhMamunur Rashid, PhD. Hard ISBN: 9781771887977 (In production)
• Shalini Mani*, ChahatKubba and Aarushi Singh. Drugs of Abuse and Addiction (2018). “Advances in Neuropharmacology: Drugs and Therapeutics”. Apple Academic Press (Taylor and Francis). Editors: Md. Sahab Uddin, RPhMamunur Rashid, PhD. Hard ISBN: 9781771887977
• Rashi Rajput, Ramneek Kaur, Rishika Chadha, Shalini Mani, Rachana R, Harleen Kaur, Manisha Singh. “The Aging Brain: From Physiology to Neurodegeneration” in the book titled Handbook of Research on Critical Examinations of Neurodegenerative Disorders." Editors:  Uddin, Md. Sahab, and Md. Shah Amran. Publisher IGI Global, ISBN13: 9781522552826 (2018)
• Shalini Mani*,Nancy Taneja, Sweekriti Jain, Manisha Singh. Anticancerous plant compounds affecting the power house of cancerous cells: A possible “Herbal Mitocan”(2017). Anticancer Plants: Mechanisms and Molecular Interactions- Volume 4. Editor(s): Mohd. Sayeed Akhtar, Dr.Mallappa Kumara Swamy. Publisher Springer Nature Singapore. ISBN 978-981-10-8416-4 ISBN 978-981-10-8417-1 (eBook).
• Shalini Mani*.Production of Reactive oxygen species and its implication in human diseases (2015). Free radicals in human health and disease. Editors Vibha Rani, Umesh Chand Singh Yadav. Publisher Springer, India, ISBN 978-81-322-2035-0

Selected Abstracts Published in Conferences

Divya Jindal, Vinayak Agarwal, Pranav Pancham, Shalini Mani, Rachana R, Shazia Haider and Manisha Singh. Fabrication and optimization of nano-emulsion system of Indian medicinal herbs for the neuroprotective activity. International Conference on Nanotechnology for Sustainable Living & Environment (ICON-NSLE 2022), held during 14-16 April 2022.

Geeta Swargiary, Shalini Mani. Nanotubes and Fullerene as Efficient Nanocarriers for Delivery of Mitocans to Hexokinase 2: An In-silico Approach. International Conference on Nanotechnology for Sustainable Living & Environment (ICON-NSLE 2022), held during 14-16 April 2022.

Sakshi Tyagi, Shalini Mani.Process Parameter Optimization ofVitamin D3 Loaded Chitosan-TPP Nanoparticles. International Conference on Nanotechnology for Sustainable Living & Environment (ICON-NSLE 2022), held during 14-16 April 2022.

Jatin Gupta, Tulika Ojha, Aastha Sachan, Manisha Singh, Shalini Mani, Shazia Haider and Rachana R. Ficus Religiosa a Potential Source of Therapeutics for Herpes Simplex Virus-I. International Conference on Nanotechnology for Sustainable Living & Environment (ICON-NSLE 2022), held during 14-16 April 2022.

Shalini Mani, Sweekriti Jain, Geeta Swargiary, Sakshi Tyagi, Manisha Singh, Dr Rachana and Shazia Haider. Mitochondria targeting ability of Nigella Sativa Seed extract in leukemia: An in-silico and in-vitro approach. International Conference on Nanotechnology for Sustainable Living & Environment (ICON-NSLE 2022), held during 14-16 April 2022.

Geeta Swargiary1, Shalini Mani. Molecular docking studies of phytocompounds derived from Centella asiatica and Andrographis paniculata to target ER and PGR. Poster presentation at 13th International conference on Frontiers in Cancer Science 2021, organized by Cancer Science Institute of Singapore, during 1-3 Nov 2021.

Shalini Mani, Geeta Swargiary. In-Silico Studies to Investigate HK2 Targeting Potential of Phytocompounds Derived from Centella Asiatica and Andrographis Paniculata. Poster presentation at 13th International conference on Frontiers in Cancer Science 2021, organized by Cancer Science Institute of Singapore, during 1-3 Nov 2021.

Shalini Mani, Geeta Swargiary, Sasha Gulati, Simmi Gupta. Molecular Docking and ADMET Studies to Predict the Anti-Breast Cancer Effect of Aloin by Targeting Estrogen and Progesterone Receptors. Materials Today Proceedings, 2021. https://doi.org/10.1016/j.matpr.2021.06.362.

Geeta Swargiary and Shalini Mani. Natural agents as a modulator of Mitochondrial Reactive Oxygen Species in Cancer Therapy. Poster presentation at 8th Annual Meeting of the Society for Mitochondria Research and Medicine-India (SMRM) -2020 virtually organized by Manipal School of Life Sciences, MAHE, Manipal during November 6-7th 2020.

Sakshi Tyagi and Shalini Mani. Synergistic effect of Metformin and Vitamin D on Cellular Bioenergetics and Hyperglycemia Poster presentation at 8th Annual Meeting of the Society for Mitochondria Research and Medicine-India (SMRM) -2020 virtually organized by Manipal School of Life Sciences, MAHE, Manipal during November 6-7th 2020.

Geeta Swargiary and Shalini Mani. ANDROGRAPHOLIDE: A POTENTIAL ANTICANCEROUS AGENT IN BREAST CANCER THERAPEUTICS BY TARGETING ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR. Research Report 2020. doi:10.9777/rr.2020.1000

Shalini Mani.Cellular Bioenergetics: A possible link between vitamin D deficiency and Type 2 diabetes. International conference on Current Perspective of Biochemistry in Health and Disease. (CAS Conference), BHU Varanasi. 11-12 January 2020.

GeetaSwargiary, Shalini Mani. Asiatic acid and Andrographolide:  Potential Herbal Mitocans. Presented at 7th Annual Conference of Society for Mitochondrial Research & Medicine, CSIR-CDRI, Lucknow. 28-30th Nov 2018

GeetaSwargiary, Shalini Mani. Molecular Docking Study of Asiatic Acid and Andrographolide with Estrogen and Progesterone receptor in Breast Cancer presented at 42nd All India Cell Biology Conference and 2nd International Conference on Trends in Cell and Molecular Biology, organized by the Indian Society of Cell Biology in BITS Pilani Goa. 21-23rd Dec 2018

NishthaSaxena, PrakritiShome, Shalini Mani. Mitochondrial Donation: A boon or curse? World Biotechnology, Congress, 20-22nd Feb 2017

Kartik Singh, GarimaDayal, DeekshaKaloni, SahilDargan, Shalini Mani. MITOCANS: Promising Anti-cancer Therapeutics. World Biotechnology Congress 20-22 February 2017

Shradha Bhatia, Rishabh Singh, Shalini Mani. MICROSKIN GRAFTING. World Biotechnology Congress 20-22 February 2017

Parul Singh, Abhishek Negi, Rachna, Manisha Singh, Shalini Mani. “Anti-stress Herbs as Alternative Therapy” World Biotechnology Congress 20-22 February 2017. Endling Conferences, JNU New Delhi

Shahrukh Hussain, Akshita Gupta, Rachana, Manisha Singh, Shalini Mani.  “Pathogenic nature of reported mt DNA mutations in Leigh’s Syndrome and MELAS: An in-silico approach” World Biotechnology Congress 20-22 February 2017. Endling Conferences, JNU New Delhi

Akshita Gupta, Shahrukh Hussain, Rachana, Manisha Singh, Shalini Mani. “Pathogenic nature of reported mt DNA mutations in LHON, AD, PD and SZ: An in-silico approach” World Biotechnology Congress 20-22 February 2017. Endling Conferences, JNU New Delhi.

Rachana, Shalini Mani, Manisha Singh. Essential Oil and their anticancer properties. World Biotechnology Congress 20-22 February 2017. Endling Conferences, JNU New Delhi.

Nancy, M. Shalini. “Vitamin D supplementation affects mitochondrial metabolism in Hyperglycemia” International conference on Mitochondria in health and disease. 10-11 February, 2017, Society for Mitochondrial Research and Medicine-India, JNU New Delhi.

Shahrukh Husain, T. Nancy, M. Shalini. “Pathogenic nature of reported mtDNA mutations in Leber’s Hereditary Optic Neuropathy: An In-silico approach” International conference on Mitochondria in health and disease. 10-11 February, 2017, Society for Mitochondrial Research and Medicine-India, JNU New Delhi

Akshita Gupta, T. Nancy, M. Shalini.“Pathogenic nature of reported mtDNA mutations in Leigh syndrome: an in silico study” International conference on Mitochondria in health and disease. 10-11 February, 2017, Society for Mitochondrial Research and Medicine-India, JNU New Delhi.

OindrilaGhoshal, Shalini Mani. Antidiabetic Herbs and Their Mechanism of Action.  International Conference on Recent Advances in Plant and Microbial Biotechnology 2-4 Feb, 2017

AarushiSaxena, Raina Jana and Vijeta Prakash, Shalini Mani. Natural products in treatment of neurological disorders. International Conference on Recent Advances in Plant and Microbial Biotechnology 2-4 Feb, 2017.

Shalini Mani.“Biotechnology in health care: Recent advances and innovations ”World Congress on Biotechnology, 15-16 December 2016. Cenetri Annual Life sciences conclave 2016, Hyderabad. (INVITED SPEAKER)

T. Nancy, M. Shalini. “Vitamin D: Pathophysiology of its Deficiency in Diabetes”. International conference on DNA structure in Health & Disease, 12-13 April 2015, AIIMS, New Delhi

S Mani. “Role of mitochondria bioenergetics in the development of Diabetes Mellitus: A potential thrust area of research”, International Conference on Health, Environment and Industrial Biotechnology, "Biosangam 2013". 21-23 Nov, 2013. MNNIT Allahabad, UP India

S. Mani. “Thiamine deficiency on heterogeneous genetic background may cause atypical phenotype of Leigh syndrome”, International Conference on Health, Environment and Industrial Biotechnology, "Biosangam 2013". 21-23 Nov, 2013.MNNIT Allahabad, UP India

VishakhaGoel, Arshpreetkalsi, Rohan Sinha, Shivangi Singh, Shalini Mani. "Stress: A potential target for Management of Diabetes. "International Conference on Health, Environment and Industrial Biotechnology (Biosangam) 21-23 Nov, 2013.MNNIT Allahabad, UP India

Arshpreetkalsi, Rohan Sinha, Shivangi Singh, VishakhaGoel, Shalini Mani. "Role of Mitochondrial bioenergetics in the development of diabetes Mellitus." Indraprastha International Conference on Biotechnology (IICB), 2013, 23-25 Oct, 2013. New Delhi, India

Kritika Sharma, Shalini Mani. “Molecular Chimerism”. International Conference on Bioproducts and the OMICS Revolution, JIIT, Noida, March 16-17, 2013.

Nikita Batra, Nitin Manocha, Somya Singh, NehaDua, ParulSuri and Shalini ManiMitochondrial quantitative and qualitative defects in Liver cancer patients: A preliminary study. 2nd Annual Conference of Society for Mitochondrial Research and Medicine-India on Mitochondria in Health and Disease, Central University of Gujrat, Nov 2-3, 2012

Shalini Mani.Genetic heterogeneity and Thiamine deficiency may together lead to atypical phenotype of Leigh syndrome. Genes, Genetics & Genomics: Today & Tomorrow- Human Concerns and XXXVII: Annual Conference of The Indian Society of Human Genetics, Punjab University, Punjab, March 3-5, 2012.

RadhikaChaddha, Ritika Shah, Krishna Sundari, Shalini Mani. Pathogenic role of SCO2 gene in Leigh syndrome patients. Genes, Genetics & Genomics: Today & Tomorrow- Human Concerns and XXXVII: Annual Conference of The Indian Society of Human Genetics, Punjab University, Punjab, March 3-5, 2012.

Pant Mamta, Basu Sujata, Shalini Maniand Rachana. In vitro anti-oxidant and cytoprotective potential of ethanolic extract of Adhatodavasica (AVE) in tobacco smoke induced oxidative stress. World Congress on Biotechnology, Leonia International Convention Centre, Hyderabad, India, May 4-6, 2012.

Shalini Mani, KarunaMadap, Kranthi Kumar, S Narasimha Rao Sidarala, G R Chandak. Clinical, Biochemical and Genetic analysis of Leigh syndrome patients with atypical presentation. Human Genome Meeting, held at Hyderabad during September 27-30, 2008.

MV Kranthi Kumar, Shalini Mani, KarunaMadap, S Narasimha Rao Sidarala, G R Chandak. High prevalence of infantile encephalitic beriberi with overlapping features of Leighs’s disease. Human Genome Meeting, held at Hyderabad during September 27-30, 2008.

Shalini Mani, Narasimha R Sidarala, VaraprasadKolla, KarunaMadap, Mohammed M Idris, Giriraj R Chandak. Mutations in ND5 gene rather than PDHE1alpha are associated with thiamine responsive Leigh Syndrome in India.  Platform presentation at Indo-US workshop on “Mitochondrial Research and Medicine” held at CCMB, Hyderabad during January 22-24, 2007.

Shalini Mani, Narasimha R Sidarala, VaraprasadKolla, KarunaMadap, Mohammed M Idris, Giriraj R Chandak. Mutations in ND5 gene rather than PDHE1alpha are associated with thiamine responsive Leigh Syndrome in India. Poster presented at 11^th International Congress of Human Genetics held at Brisbane, Australia during August 6-10, 2006.

Shalini Mani, NR Sidrala, V Kolla, K Madap, MM Idris, and G R Chandak. Genetic analysis of PDHE1alpha and ND5 genes in thiamine responsive Leigh syndrome. Platform presentation at XXIX All India Cell Biology Conference and symposium on “Gene to Genome: Environment and chemical interaction” held at ITRC Lucknow during January 17-20, 2006.

PROJECTS

Designing an alternative cancer therapy by study of anticncerous herbs for their potential mitocan activity. NFST (Ministry of Tribal affair). Duration: 2018-23. Grant amount: 22.082 Lacs (As Mentor)

Co-administration of Metformin and Vitamin D for their additive antihyperglycemic effects of nano-formulation for their enhanced targeting and efficacy: An in-vitro study.” Indian council of Medical Research (Govt of India). Duration 2022-2025. Grant amount: 23 Lacs (approx.). (As Mentor)

AWARDS/FELLOWSHIPS/CERTIFICATES                                                                                                                                      

• Endeavour Research fellowship, 2015. Australia.
• Second best oral presentation award, titled” Thiamine deficiency on heterogeneous genetic background may cause atypical phenotype of Leigh syndrome” in International Conference on Health, Environment and Industrial Biotechnology (Biosangam), held at MLNIIT, Allahabad, 21-23 Nov, 2013
• Travel grant support by Dept. of Biotechnology, Govt of India to present a paper in the 11^th ICHG at Brisbane, Australia during August 6-10, 2006.
• Travel grant support by Dept. of Science and Technology, Govt of India to present a paper in the 11^th ICHG at Brisbane, Australia during August 6-10, 2006.
• Senior research fellowship (2006-08) from Council of Scientific and Industrial Research, New Delhi (India)
• Junior research fellowship (2003-06) from Council of Scientific and Industrial Research, New Delhi (India)
• Graduate Aptitude Test in Engineering (GATE, 2002) with 90.15 percentile and all India 225thrank.
• Department of Biotechnology government of India studentship (2000-02) for pursuing M.Sc Biotechnology.

MEMBER OF PROFESSIONAL BODIES

• Society for Mitochondrial Research and Medicine (2014-till date) 

• Indian genome Variation database

• Member of British Neuroscience Association (BNA)

• Member of ISTAART (The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment)

• Editorial Board member of American Journal of Biomedical and Life Sciences

• Editorial Board member of Integrative Diabetes and Cardiovascular Diseases

• Invited guest reviewer for various reputed journals such as Mitochondrion, Frontiers, Polymorphisms,

EDITORIAL MEMBER

• Editorial Board member of American Journal of Biomedical and Life Sciences

• Editorial Board member of Integrative Diabetes and Cardiovascular Diseases
• Guest Editor Research Report
• Guest Editor Polymorphisms
• Guest Editor of Journal of Herbal Medicine
• Guest Editor of Egyptian Journal of Medical Human Genetics

Ph.D STUDENTS (COMPLETED): (1)

Ph.D STUDENTS (ONGOING): (2)